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uORF Shuffling Fine-Tunes Gene Expression at a Deep Level of the Process

Synthetic Genomics Research Group, RIKEN Center for Sustainable Resource Science, 1-7-22 Suehirocho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
Plants 2020, 9(5), 608; https://doi.org/10.3390/plants9050608
Received: 8 April 2020 / Revised: 6 May 2020 / Accepted: 8 May 2020 / Published: 11 May 2020
(This article belongs to the Special Issue Plant Systems and Application)
Upstream open reading frames (uORFs) are present in the 5’ leader sequences (or 5’ untranslated regions) upstream of the protein-coding main ORFs (mORFs) in eukaryotic polycistronic mRNA. It is well known that a uORF negatively affects translation of the mORF. Emerging ribosome profiling approaches have revealed that uORFs themselves, as well as downstream mORFs, can be translated. However, it has also been revealed that plants can fine-tune gene expression by modulating uORF-mediated regulation in some situations. This article reviews several proposed mechanisms that enable genes to escape from uORF-mediated negative regulation and gives insight into the application of uORF-mediated regulation for precisely controlling gene expression. View Full-Text
Keywords: uORF; translation; ribosome; NMD uORF; translation; ribosome; NMD
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MDPI and ACS Style

Kurihara, Y. uORF Shuffling Fine-Tunes Gene Expression at a Deep Level of the Process. Plants 2020, 9, 608. https://doi.org/10.3390/plants9050608

AMA Style

Kurihara Y. uORF Shuffling Fine-Tunes Gene Expression at a Deep Level of the Process. Plants. 2020; 9(5):608. https://doi.org/10.3390/plants9050608

Chicago/Turabian Style

Kurihara, Yukio. 2020. "uORF Shuffling Fine-Tunes Gene Expression at a Deep Level of the Process" Plants 9, no. 5: 608. https://doi.org/10.3390/plants9050608

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