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Plants 2019, 8(2), 40;

Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research

Department of Pharmacognosy, Botany and Technology of Phytopreparations, Pyatigorsk Medical-Pharmaceutical Institute (PMPI), Branch of Volgograd State Medical University, Ministry of Health of Russia, Pyatigorsk 357532, Russia
South Kazakhstan State Pharmaceutical Academy, Shymkent 160019, Kazakhstan
Author to whom correspondence should be addressed.
Received: 10 December 2018 / Revised: 6 February 2019 / Accepted: 11 February 2019 / Published: 12 February 2019
(This article belongs to the Special Issue Plant Phytochemicals on Crop Protection and Biotechnology)
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For many years, plants have been used in the traditional medicine of different cultures. The biennial plant of the family Asteraceae, Onopordum acanthium L., also known as Scotch thistle, is used in traditional medicine as an anti-inflammatory, antitumor, and cardiotonic agent. The plant is widespread in the world; it grows in Europe and Asia and was introduced to America and Australia. Stems and buds of the first-year plant are used in cooking as an analogue of artichoke in European cuisine. Additionally, inflorescences contain a complex of proteolytic enzymes “onopordosin”, which may be used as a milk-clotting agent in the dairy industry. The chemical composition of the aerial part and roots of O. acanthium is represented by flavonoids, phenylpropanoids, lignans, triterpenoids, sesquiterpene lactones, and sterols. The anti-inflammatory, antiproliferative, and cardiotonic properties of the plant have been confirmed by pharmacological experiments with extracts and individual compounds using in silico, in vitro, and in vivo methods. This work is a review of information on the chemical composition and pharmacological studies of O. acanthium as a promising medicinal plant. View Full-Text
Keywords: Onopordum acanthium; Asteraceae; metabolites; pharmacology; antitumor; anti-inflammatory activity Onopordum acanthium; Asteraceae; metabolites; pharmacology; antitumor; anti-inflammatory activity

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Garsiya, E.R.; Konovalov, D.A.; Shamilov, A.A.; Glushko, M.P.; Orynbasarova, K.K. Traditional Medicine Plant, Onopordum acanthium L. (Asteraceae): Chemical Composition and Pharmacological Research. Plants 2019, 8, 40.

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