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Volume 8
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10.3390/plants8110494
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Article

In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products

by
Reginaldo dos Santos Pedroso
1,2,3,†,
Brenda Lorena Balbino
1,†,
Géssica Andrade
1,
Maria Cecilia Pereira Sacardo Dias
1,
Tavane Aparecida Alvarenga
1,
Rita Cássia Nascimento Pedroso
1,
Letícia Pereira Pimenta
1,
Rodrigo Lucarini
1,
Patrícia Mendonça Pauletti
1,
Ana Helena Januário
1,
Marco Túlio Menezes Carvalho
4,
Mayker Lazaro Dantas Miranda
5 and
Regina Helena Pires
1,*
1
Universidade de Franca, Franca 14404-600, SP, Brazil
2
Escola Técnica de Saúde, Universidade Federal de Uberlândia, Uberlândia 38400-902, MG, Brazil
3
Programa de Pós-graduação em Ciências da Saúde, Universidade Federal de Uberlândia, Uberlândia 38400-902, MG, Brazil
4
Universidade Estadual de Minas Gerais, Passos 37902-407, MG, Brazil
5
Instituto Federal do Triângulo Mineiro, Campus Uberlândia Centro, Uberlândia 38.064-300, MG, Brazil
*
Author to whom correspondence should be addressed.
†
Both authors contributed equally to this work.
Plants 2019, 8(11), 494; https://doi.org/10.3390/plants8110494
Submission received: 15 September 2019 / Revised: 14 October 2019 / Accepted: 8 November 2019 / Published: 11 November 2019
(This article belongs to the Special Issue Antimicrobial Compounds in Plants)
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Abstract

Candidiasis therapy, especially for candidiasis caused by Candida non-albicans species, is limited by the relatively reduced number of antifungal drugs and the emergence of antifungal tolerance. This study evaluates the anticandidal activity of 41 plant-derived products against Candida species, in both planktonic and biofilm cells. This study also evaluates the toxicity and the therapeutic action of the most active compounds by using the Caenorhabditis elegans–Candida model. The planktonic cells were cultured with various concentrations of the tested agents. The Cupressus sempervirens, Citrus limon, and Litsea cubeba essential oils as well as gallic acid were the most active anticandidal compounds. Candida cell re-growth after treatment with these agents for 48 h demonstrated that the L. cubeba essential oil and gallic acid displayed fungistatic activity, whereas the C. limon and C. sempervirens essential oils exhibited fungicidal activity. The C. sempervirens essential oil was not toxic and increased the survival of C. elegans worms infected with C. glabrata or C. orthopsilosis. All the plant-derived products assayed at 250 µg/mL affected C. krusei biofilms. The tested plant-derived products proved to be potential therapeutic agents against Candida, especially Candida non-albicans species, and should be considered when developing new anticandidal agents.
Keywords: plant-derived products; Candida; C. elegans; anticandidal agents plant-derived products; Candida; C. elegans; anticandidal agents

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MDPI and ACS Style

Pedroso, R.d.S.; Balbino, B.L.; Andrade, G.; Dias, M.C.P.S.; Alvarenga, T.A.; Pedroso, R.C.N.; Pimenta, L.P.; Lucarini, R.; Pauletti, P.M.; Januário, A.H.; et al. In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products. Plants 2019, 8, 494. https://doi.org/10.3390/plants8110494

AMA Style

Pedroso RdS, Balbino BL, Andrade G, Dias MCPS, Alvarenga TA, Pedroso RCN, Pimenta LP, Lucarini R, Pauletti PM, Januário AH, et al. In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products. Plants. 2019; 8(11):494. https://doi.org/10.3390/plants8110494

Chicago/Turabian Style

Pedroso, Reginaldo dos Santos, Brenda Lorena Balbino, Géssica Andrade, Maria Cecilia Pereira Sacardo Dias, Tavane Aparecida Alvarenga, Rita Cássia Nascimento Pedroso, Letícia Pereira Pimenta, Rodrigo Lucarini, Patrícia Mendonça Pauletti, Ana Helena Januário, and et al. 2019. "In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products" Plants 8, no. 11: 494. https://doi.org/10.3390/plants8110494

APA Style

Pedroso, R. d. S., Balbino, B. L., Andrade, G., Dias, M. C. P. S., Alvarenga, T. A., Pedroso, R. C. N., Pimenta, L. P., Lucarini, R., Pauletti, P. M., Januário, A. H., Carvalho, M. T. M., Miranda, M. L. D., & Pires, R. H. (2019). In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products. Plants, 8(11), 494. https://doi.org/10.3390/plants8110494

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