Next Article in Journal
Dimensional Changes of Tracheids during Drying of Radiata Pine (Pinus radiata D. Don) Compression Woods: A Study Using Variable-Pressure Scanning Electron Microscopy (VP-SEM)
Next Article in Special Issue
A Comprehensive Review on the Medicinal Plants from the Genus Asphodelus
Previous Article in Journal
Evidence of Adaptation to Recent Changes in Atmospheric CO2 in Four Weedy Species
Previous Article in Special Issue
Genus-Specific Real-Time PCR and HRM Assays to Distinguish Liriope from Ophiopogon Samples
Open AccessArticle

Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses

1
VivaCell Biotechnology GmbH, Denzlingen 79211, Germany
2
VivaCell Biotechnology España, Córdoba 14004, Spain
3
Dr. Loges + Co. GmbH, Winsen 21423, Germany
*
Author to whom correspondence should be addressed.
Plants 2018, 7(1), 13; https://doi.org/10.3390/plants7010013
Received: 5 December 2017 / Revised: 22 January 2018 / Accepted: 23 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Medicinal Plants and Natural Product Research)
Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is well documented that Spirulina exerts anti-inflammatory effects and showed promising effects with respect to the relief of allergic rhinitis symptoms. Taking into account these findings, we decided to elucidate whether Immulina®, and immunLoges® (a commercial available multicomponent nutraceutical with Immulina® as a main ingredient) beyond immune-enhancing effects, might also exert inhibitory effects in the induced allergic inflammatory response and on histamine release from RBL-2H3 mast cells. Our findings show that Immulina® and immunLoges® inhibited the IgE-antigen complex-induced production of TNF-α, IL-4, leukotrienes and histamine. The compound 48/80 stimulated histamine release in RBL-2H3 cells was also inhibited. Taken together, our results showed that Immulina® and immunLoges® exhibit anti-inflammatory properties and inhibited the release of histamine from mast cells. View Full-Text
Keywords: allergy; inflammation; mast cells; Immulina®; immunLoges® allergy; inflammation; mast cells; Immulina®; immunLoges®
Show Figures

Figure 1

MDPI and ACS Style

Appel, K.; Munoz, E.; Navarrete, C.; Cruz-Teno, C.; Biller, A.; Thiemann, E. Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses. Plants 2018, 7, 13. https://doi.org/10.3390/plants7010013

AMA Style

Appel K, Munoz E, Navarrete C, Cruz-Teno C, Biller A, Thiemann E. Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses. Plants. 2018; 7(1):13. https://doi.org/10.3390/plants7010013

Chicago/Turabian Style

Appel, Kurt; Munoz, Eduardo; Navarrete, Carmen; Cruz-Teno, Cristina; Biller, Andreas; Thiemann, Eva. 2018. "Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses" Plants 7, no. 1: 13. https://doi.org/10.3390/plants7010013

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop