Plants 2018, 7(1), 13; https://doi.org/10.3390/plants7010013
Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses
Kurt Appel 1, Eduardo Munoz 2, Carmen Navarrete 2, Cristina Cruz-Teno 2, Andreas Biller 3 and Eva Thiemann 3,*
1
VivaCell Biotechnology GmbH, Denzlingen 79211, Germany
2
VivaCell Biotechnology España, Córdoba 14004, Spain
3
Dr. Loges + Co. GmbH, Winsen 21423, Germany
*
Author to whom correspondence should be addressed.
Received: 5 December 2017 / Revised: 22 January 2018 / Accepted: 23 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Medicinal Plants and Natural Product Research)
Abstract
Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is well documented that Spirulina exerts anti-inflammatory effects and showed promising effects with respect to the relief of allergic rhinitis symptoms. Taking into account these findings, we decided to elucidate whether Immulina®, and immunLoges® (a commercial available multicomponent nutraceutical with Immulina® as a main ingredient) beyond immune-enhancing effects, might also exert inhibitory effects in the induced allergic inflammatory response and on histamine release from RBL-2H3 mast cells. Our findings show that Immulina® and immunLoges® inhibited the IgE-antigen complex-induced production of TNF-α, IL-4, leukotrienes and histamine. The compound 48/80 stimulated histamine release in RBL-2H3 cells was also inhibited. Taken together, our results showed that Immulina® and immunLoges® exhibit anti-inflammatory properties and inhibited the release of histamine from mast cells. View Full-TextKeywords:
allergy; inflammation; mast cells; Immulina®; immunLoges®
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Appel, K.; Munoz, E.; Navarrete, C.; Cruz-Teno, C.; Biller, A.; Thiemann, E. Immunomodulatory and Inhibitory Effect of Immulina®, and Immunloges® in the Ig-E Mediated Activation of RBL-2H3 Cells. A New Role in Allergic Inflammatory Responses. Plants 2018, 7, 13.
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