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Systematic Review
Peer-Review Record

Opuntia ficus-indica Fruit: A Systematic Review of Its Phytochemicals and Pharmacological Activities

by Luis Giraldo-Silva 1,2, Bárbara Ferreira 1,2, Eduardo Rosa 2 and Alberto C. P. Dias 1,*
Reviewer 1: Anonymous
Reviewer 2:
Submission received: 8 December 2022 / Revised: 13 January 2023 / Accepted: 16 January 2023 / Published: 25 January 2023

Round 1

Reviewer 1 Report

att

Comments for author File: Comments.docx

Author Response

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Author Response File: Author Response.docx

Reviewer 2 Report

It is a high-quality review of the Opuntia-ficus indica plant's phytochemistry and biological-pharmacological properties. I have one major comment and some editing points to be amended for overall improvement.

1) The only thing I miss in this very good review is the connection (or at least an attempt) of the pharmacological properties with bioactive chemicals identified and reported. I recommend the authors to add a respective paragraph to show this connection with exemplary works (2-3 are enough). 

2) Minor comments: Page 1 Abstract line 12 "intend", line 27, please add "Crassulaveau acid metabolism" before the abbreviation CAM. Page 2, lines 83-85 need to be rephrased. Page 3, line 105, records are 368 or 369? Page 6, line 172, delete "E.g." and begin with "For instance". Page 12, I see repeated paragraphs of page 10, please check and omit when required. Page 15, line 455 "tests". General comment, be consistent with "mL" in the text (capital L i mean). 

Author Response

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Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Att.

Comments for author File: Comments.docx

Author Response

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Author Response File: Author Response.docx

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