The Protective Role of Cranberries and Blueberries in Oral Cancer
Abstract
:1. Background
2. Materials and Methods
3. Introduction
3.1. Head and Neck Cancer
3.2. Oral Cancer
3.3. Epidemiology
3.4. Etiology and Risk Factors
3.4.1. Tobacco
3.4.2. Alcohol
3.4.3. Viral Infections
Human Papillomavirus
Epstein–Barr Virus
3.4.4. Oral Health
3.4.5. Diet and Nutrition
3.5. Premalignant Lesions
3.5.1. Leucoplakia
3.5.2. Erythroplasia
3.5.3. Lichen Planus
3.6. Histological Aspects of Oral Cancer
3.7. Carcinogenesis of Oral Cancer
3.7.1. Oncogenes and Tumor Suppressor Genes
3.7.2. Epigenetic Alterations
4. Treatment
Prevention and Antioxidants
5. Phytochemical Compounds
5.1. Family Ericaceae
5.2. Anthocyanidins
5.3. Anthocyanins
5.4. Flavan-3-ols and Proanthocyanidins
5.5. Phenolic Acids
5.6. Triterpenoids
6. Berries and Cancer
6.1. Mechanism of Action of Berries in Cancer
6.2. Mechanism of Action of Berry-Derived Phytochemicals in Oral Cancer
6.3. Consumption of Cranberries and Blueberries in Protection against Risk Factors for Oral Cancer
6.3.1. Cranberries and Blueberries and Their Protection against Tobacco-Induced Oral Cancer
6.3.2. Cranberries and Blueberries and Their Protection against Alcohol-Induced Oral Cancer
6.4. Consumption of Cranberries and Blueberries Protects against the Effects of Bacteria and Poor Oral Hygiene
6.5. Cranberries and Blueberries and Their Protection against Oral Cancer Induced by Viral Infections
Cranberry Type | Type of Study Conducted (In Vitro/In Vivo/Clinical Study) | Evidence against Oral Cancer | Reference |
---|---|---|---|
Vaccinium corymbosum L. (blueberries) | In vitro | The methanolic extract of blueberries inhibits cell proliferation in the oral cancer line KB. | [128,188] |
In vivo/In vitro | Dietary administration of blueberry produces significant effects on the SCC131 cancer cell line through the inhibition of TGF-β and NF-κB, as well as act against invasion and angiogenesis at doses higher than 200 mg/kg. | [20,167] | |
In vitro | The phytochemical pterostilbene present in blueberries induces apoptotic cell death and, through autophagy in cisplatin-resistant human oral cancer cells (CAR cells), which is related to the AKT pathway, are mediated by the suppression of MDR1. | [100] | |
Vaccinium macrocarpon A. (lingonberries) | In vitro | The methanol extract of the cranberries inhibits cellular proliferation in the line of oral cancer KB. | [128,188] |
In vivo/In vitro | The extract composed of proanthocyanidins (C-PAC) derived from cranberries inhibits the growth of resistant and acid-sensitive esophageal adenocarcinoma (EAC) cells, both in cell lines and xenotransplant mice, inducing caspase-independent cell death, mainly by the autophagic pathway. | [131] | |
In vitro | The hydroethanolic extract of cranberries produces an antiproliferative effect on the caspase-independent KB cell line, mainly by the autophagic route. | [190] | |
In vitro | Cranberry extract produces an inhibitory effect on the proliferation of OSCC lines cAL27 and SCC25 at an optimal concentration of 40 μg/mL, producing the upstream regulation of caspases 2 and 8, and effects cell adhesion, cell morphology, and the cell cycle. | [191] |
7. Limitations and Perspectives of the Consumption of Cranberries and Blueberries for Protection against Oral Cancer
Limitations
8. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
OSCC | Oral squamous carcinoma cell |
HPV | Human papillomavirus |
EBV | Epstein–Barr virus |
NNN | N′-nitrosonornicotine |
NNK | 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone |
ROS | Reactive oxygen species |
BMI | Body mass index |
EGFR/c-erb | Epidermal growth factor receptor |
TNF | tumor necrosis factor |
MMP | matrix metalloproteinase |
CAL-27 | oral cancer cell line |
C3G | cyanidin-3-glucoside |
PACs | Proanthocyanidins |
COX-2 | Cyclooxygenase 2 |
MMP-9 | Matrix metalloproteinase-9 |
VEGF-A | Vascular endothelial growth factor A |
NF-κB | Nuclear transcription factor |
NOSs | Nitric oxide synthases |
P3G | pelargonidin-3-glucoside |
SCC131 | oral cancer cell line 131 |
PI3K | phosphoinositide-3-kinase |
AKT | Protein kinase B |
mTOR | the mammalian target of rapamycin |
MAP | Mitogen-activated protein kinase |
PKA | cAMP-dependent protein kinaseB |
AMPK | the AMP-activated protein kinase |
TGF-β | Transforming growth factor-β |
STAT-3 | Signal transducer and activator of transcription 3 |
JAK/STAT | The Janus-Kinase signal transducer and the transcription activation pathway |
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Secondary Metabolite | Average Concentration in the Extract * | Reference: |
---|---|---|
Vaccinium corymbosum L. (blueberries) | ||
Phenolic acids | ||
Hydroxybenzoic acid | 1.5 mg/kg fw | [132] |
Hydroxycinnamic acid | 135 mg/kg fw | [132] |
Flavonoids | [132] | |
Flavonols | 38.7 mg/kg fw | [132] |
Anthocyanins | 134 mg/kg fw | [132] |
Vaccinium macrocarpon A. (lingonberries) | ||
Anthocyanins | 695–1716 mg/100 g dm | [99] |
Phenolic acids | 327–649 mg/100 g dm | [99] |
Flavonols | 643–1088 mg/100 g dm | [99] |
Flavan-3-ols and proanthocyanidins | 860–1283 mg/100 g dm | [99] |
Triterpenoids | 2528–3201.5 mg/kg dm | [99] |
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Esquivel-Chirino, C.; Bolaños-Carrillo, M.A.; Carmona-Ruiz, D.; Lopéz-Macay, A.; Hernández-Sánchez, F.; Montés-Sánchez, D.; Escuadra-Landeros, M.; Gaitán-Cepeda, L.A.; Maldonado-Frías, S.; Yáñez-Ocampo, B.R.; et al. The Protective Role of Cranberries and Blueberries in Oral Cancer. Plants 2023, 12, 2330. https://doi.org/10.3390/plants12122330
Esquivel-Chirino C, Bolaños-Carrillo MA, Carmona-Ruiz D, Lopéz-Macay A, Hernández-Sánchez F, Montés-Sánchez D, Escuadra-Landeros M, Gaitán-Cepeda LA, Maldonado-Frías S, Yáñez-Ocampo BR, et al. The Protective Role of Cranberries and Blueberries in Oral Cancer. Plants. 2023; 12(12):2330. https://doi.org/10.3390/plants12122330
Chicago/Turabian StyleEsquivel-Chirino, César, Mario Augusto Bolaños-Carrillo, Daniela Carmona-Ruiz, Ambar Lopéz-Macay, Fernando Hernández-Sánchez, Delina Montés-Sánchez, Montserrat Escuadra-Landeros, Luis Alberto Gaitán-Cepeda, Silvia Maldonado-Frías, Beatriz Raquel Yáñez-Ocampo, and et al. 2023. "The Protective Role of Cranberries and Blueberries in Oral Cancer" Plants 12, no. 12: 2330. https://doi.org/10.3390/plants12122330