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Review

A Review and Evaluation of the Data Supporting Internal Use of Helichrysum italicum

1
Faculty of Health Sciences, University of Primorska, 6310 Izola, Slovenia
2
Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia
3
Faculty of Pharmacy, University of Ljubljana, 1000 Ljubljana, Slovenia
*
Author to whom correspondence should be addressed.
Academic Editors: Sofia Rhizopoulou, Maria Karatassiou and Efi Levizou
Plants 2021, 10(8), 1738; https://doi.org/10.3390/plants10081738
Received: 23 July 2021 / Revised: 17 August 2021 / Accepted: 18 August 2021 / Published: 23 August 2021
(This article belongs to the Special Issue Mediterranean Plants)
Helichrysum italicum is a Mediterranean plant with various pharmacological activities. Despite extensive reports on the bioactivity of the plant, its clinically studied applications have not yet been reviewed. The aim of our study was to gather information on the internal use of H. italicum and its bioactive constituents to determine its efficacy and safety for human use. We reviewed research articles that have not been previously presented in this context and analyzed relevant clinical studies with H. italicum. Cochranelibrary.com revealed six eligible clinical trials with H. italicum that examined indications for pain management, cough, and mental exhaustion. Although the efficacy of H. italicum has been demonstrated both in in vitro tests and in humans, it is difficult to attribute results from clinical trials to H. italicum alone, as it has usually not been tested as the sole component. On the other hand, clinical trials provide positive information on the safety profile since no adverse effects have been reported. We conclude that H. italicum is safe to use internally, while new clinical studies with H. italicum as a single component are needed to prove its efficacy. Based on the recent trend in H. italicum research, further studies are to be expected. View Full-Text
Keywords: Helichrysum italicum; biological activity; internal use; clinical studies Helichrysum italicum; biological activity; internal use; clinical studies
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MDPI and ACS Style

Kramberger, K.; Kenig, S.; Jenko Pražnikar, Z.; Kočevar Glavač, N.; Barlič-Maganja, D. A Review and Evaluation of the Data Supporting Internal Use of Helichrysum italicum. Plants 2021, 10, 1738. https://doi.org/10.3390/plants10081738

AMA Style

Kramberger K, Kenig S, Jenko Pražnikar Z, Kočevar Glavač N, Barlič-Maganja D. A Review and Evaluation of the Data Supporting Internal Use of Helichrysum italicum. Plants. 2021; 10(8):1738. https://doi.org/10.3390/plants10081738

Chicago/Turabian Style

Kramberger, Katja, Saša Kenig, Zala Jenko Pražnikar, Nina Kočevar Glavač, and Darja Barlič-Maganja. 2021. "A Review and Evaluation of the Data Supporting Internal Use of Helichrysum italicum" Plants 10, no. 8: 1738. https://doi.org/10.3390/plants10081738

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