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Review

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

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Research Institute of Biotechnology & Medical Converged Science, Dongguk University-Seoul, Goyang-si 10326, Korea
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Department of Food Science & Biotechnology, Dongguk University-Seoul, Goyang-si 10326, Korea
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Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Cosenza, Italy
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MED—Mediterranean Institute for Agriculture, Environment and Development, Universidade do Algarve, Faculdade de Ciências e Tecnologia, Campus de Gambelas, Ed. 8, 8005-139 Faro, Portugal
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College of Medicine, University of the Philippines Manila, Manila 1000, Philippines
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Observatory of Drug-Herb Interactions, Faculty of Pharmacy, University of Coimbra, Heath Sciences Campus, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal
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Coimbra Chemistry Centre (CQC, FCT Unit 313) (FCTUC), University Coimbra, Rua Larga, 3004-535 Coimbra, Portugal
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Department of Drug and Health Science—Biochemistry Section, University of Catania, Viale A. Doria 6, 95125 Catania, Italy
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Department of Chemistry, University of Connecticut, Storrs, CT 06269, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Anna Oniszczuk and Karolina Wojtunik-Kulesza
Plants 2021, 10(5), 846; https://doi.org/10.3390/plants10050846
Received: 17 March 2021 / Revised: 16 April 2021 / Accepted: 19 April 2021 / Published: 22 April 2021
(This article belongs to the Special Issue Advances in Functional Food Products Derived from Plant)
Valerianaceae, the sub-family of Caprifoliaceae, contains more than 300 species of annual and perennial herbs, worldwide distributed. Several species are used for their biological properties while some are used as food. Species from the genus Valeriana have been used for their antispasmodic, relaxing, and sedative properties, which have been mainly attributed to the presence of valepotriates, borneol derivatives, and isovalerenic acid. Among this genus, the most common and employed species is Valerianaofficinalis. Although valerian has been traditionally used as a mild sedative, research results are still controversial regarding the role of the different active compounds, the herbal preparations, and the dosage used. The present review is designed to summarize and critically describe the current knowledge on the different plant species belonging to Valerianaceae, their phytochemicals, their uses in the treatment of different diseases with particular emphasis on the effects on the central nervous system. The available information on this sub-family was collected from scientific databases up until year 2020. The following electronic databases were used: PubMed, Scopus, Sci Finder, Web of Science, Science Direct, NCBI, and Google Scholar. The search terms used for this review included Valerianaceae, Valeriana, Centranthus, Fedia, Patrinia, Nardostachys, Plectritis, and Valerianella, phytochemical composition, in vivo studies, Central Nervous System, neuroprotective, antidepressant, antinociceptive, anxiolytic, anxiety, preclinical and clinical studies. View Full-Text
Keywords: Valerianaceae; anxiolytic; sedative; myorelaxant; antidepressant; biological activities; clinical studies; phytochemicals; valerian Valerianaceae; anxiolytic; sedative; myorelaxant; antidepressant; biological activities; clinical studies; phytochemicals; valerian
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MDPI and ACS Style

Das, G.; Shin, H.-S.; Tundis, R.; Gonçalves, S.; Tantengco, O.A.G.; Campos, M.G.; Acquaviva, R.; Malfa, G.A.; Romano, A.; Robles, J.A.H.; Clores, M.Q.; Patra, J.-K. Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System. Plants 2021, 10, 846. https://doi.org/10.3390/plants10050846

AMA Style

Das G, Shin H-S, Tundis R, Gonçalves S, Tantengco OAG, Campos MG, Acquaviva R, Malfa GA, Romano A, Robles JAH, Clores MQ, Patra J-K. Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System. Plants. 2021; 10(5):846. https://doi.org/10.3390/plants10050846

Chicago/Turabian Style

Das, Gitishree, Han-Seung Shin, Rosa Tundis, Sandra Gonçalves, Ourlad A.G. Tantengco, Maria G. Campos, Rosaria Acquaviva, Giuseppe A. Malfa, Anabela Romano, Joyce A.H. Robles, Mariel Q. Clores, and Jayanta-Kumar Patra. 2021. "Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System" Plants 10, no. 5: 846. https://doi.org/10.3390/plants10050846

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