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Article

Biological Properties of Essential Oils from Thymus algeriensis Boiss

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Chemistry Department, University of Hamma Lakhdar, B.P.789, 39000 El-Oued, Algeria
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Technical Platform of Physico-Chemical Analysis (PTAPC-Laghouat-CRAPC), P.O. Box. 37G, Road of Ghardaïa, 03000 Laghouat, Algeria
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Nuclear Research Centre of Birine, P.O. Box 180, Ain Oussera, 17200 Djelfa, Algeria
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Department of Plant Production Technology and Commodities Science, University of Life Science in Lublin, Akademicka 15 str., 20-950 Lublin, Poland
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Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo—Ourense Campus, E32004 Ourense, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Lina Raudone
Plants 2021, 10(4), 786; https://doi.org/10.3390/plants10040786
Received: 18 March 2021 / Revised: 12 April 2021 / Accepted: 14 April 2021 / Published: 16 April 2021
(This article belongs to the Special Issue Trends in Plants Phytochemistry and Bioactivity Analysis)
This study describes the chemical composition, antitumor, antioxidant, and antimicrobial activities of the plant Thymus algeriensis Boiss. Essential oils (EOs) were collected in different periods (before, during, and after flowering stage) from the El-Guetfa region, M’sila, Algeria. The EOs extraction was achieved using three distinguishing techniques: hydro (Clevenger trap), steam, and microwave distillations, targeting different aerial parts of the plant (stems, flowers, and leaves). The EOs chemical components were estimated using GC-FID and GC-MS apparatuses. The resulting yield of the extracted oil was moderate and ranged between 0.84 and 1.53% (wt/vol). In total, eighty-five components were identified, in which the oxygenated monoterpenes family formed the main portion, starting from 40.56 up to 70.66%. The obtained essential oil was dominated by five major components that varied from low to quite moderate percentages: camphor (17.45–32.56%), borneol (11.16–22.2%), camphene (7.53–12.86%), 1.8-cineole (5.16–11.21%), and bornyl acetate (3.86–7.92%). The biological results of this oil pointed out that the EOs extracted from the leaves part exposed a weak radical scavenging activity afterward using two well-known antioxidant assays DPPH (IC50 = 8.37 mg/mL) and ABTS (10.84 mg/mL). Meanwhile, this oil presented strong inhibition activity against colon cancer cell line HCT116 (LC50 = 39.8 µg/mL) and a moderate inhibitory against hepatocellular cancer cells HePG2 (LC50 > 100 µg/mL). In addition, this oil antimicrobial activity was quite important against Micrococcus luteus (M. luteus), Staphylococcus aureus CIP 7625, Escherichia coli ATCC 10536, Saccharomyces cerevisiae ATCC 4226, Candida albicans IPA200, Candida tropicalis (Ct), and Candida glabrata (Cg) after using Amoxicillin and Itraconazole as references. View Full-Text
Keywords: Thymus algeriensis Boiss; essential oils; chemical composition; GC-MS; antitumor activity; antimicrobial activity; antioxidant activity Thymus algeriensis Boiss; essential oils; chemical composition; GC-MS; antitumor activity; antimicrobial activity; antioxidant activity
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MDPI and ACS Style

Ouakouak, H.; Benarfa, A.; Messaoudi, M.; Begaa, S.; Sawicka, B.; Benchikha, N.; Simal-Gandara, J. Biological Properties of Essential Oils from Thymus algeriensis Boiss. Plants 2021, 10, 786. https://doi.org/10.3390/plants10040786

AMA Style

Ouakouak H, Benarfa A, Messaoudi M, Begaa S, Sawicka B, Benchikha N, Simal-Gandara J. Biological Properties of Essential Oils from Thymus algeriensis Boiss. Plants. 2021; 10(4):786. https://doi.org/10.3390/plants10040786

Chicago/Turabian Style

Ouakouak, Hamza, Adel Benarfa, Mohammed Messaoudi, Samir Begaa, Barbara Sawicka, Naima Benchikha, and Jesus Simal-Gandara. 2021. "Biological Properties of Essential Oils from Thymus algeriensis Boiss" Plants 10, no. 4: 786. https://doi.org/10.3390/plants10040786

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