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Article

Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival

1
Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, I-70124 Bari, Italy
2
Department of General Surgery, University Hospital Polyclinic, I-70124 Bari, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Antonella Smeriglio and Francesca Pintus
Plants 2021, 10(2), 286; https://doi.org/10.3390/plants10020286
Received: 30 December 2020 / Revised: 31 January 2021 / Accepted: 1 February 2021 / Published: 3 February 2021
(This article belongs to the Special Issue Research of Bioactive Substances in Plant Extracts)
Extra virgin olive oil (EVOO) is a major component of the Mediterranean diet and is appreciated worldwide because of its nutritional benefits in metabolic diseases, including type 2 diabetes (T2D). EVOO contains significant amounts of secondary metabolites, such as phenolic compounds (PCs), that may positively influence the metabolic status. In this study, we investigated for the first time the effects of several PCs on beta-cell function and survival. To this aim, INS-1E cells were exposed to 10 μM of the main EVOO PCs for up to 24 h. Under these conditions, survival, insulin biosynthesis, glucose-stimulated insulin secretion (GSIS), and intracellular signaling activation (protein kinase B (AKT) and cAMP response element-binding protein (CREB)) were evaluated. Hydroxytyrosol, tyrosol, and apigenin augmented beta-cell proliferation and insulin biosynthesis, and apigenin and luteolin enhanced the GSIS. Conversely, vanillic acid and vanillin were pro-apoptotic for beta-cells, even if they increased the GSIS. In addition, oleuropein, p-coumaric, ferulic and sinapic acids significantly worsened the GSIS. Finally, a mixture of hydroxytyrosol, tyrosol, and apigenin promoted the GSIS in human pancreatic islets. Apigenin was the most effective compound and was also able to activate beneficial intracellular signaling. In conclusion, this study shows that hydroxytyrosol, tyrosol, and apigenin foster beta-cells’ health, suggesting that EVOO or supplements enriched with these compounds may improve insulin secretion and promote glycemic control in T2D patients. View Full-Text
Keywords: extra virgin olive oil; phenolic compounds; diabetes; pancreatic beta-cells; insulin; apigenin extra virgin olive oil; phenolic compounds; diabetes; pancreatic beta-cells; insulin; apigenin
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MDPI and ACS Style

Marrano, N.; Spagnuolo, R.; Biondi, G.; Cignarelli, A.; Perrini, S.; Vincenti, L.; Laviola, L.; Giorgino, F.; Natalicchio, A. Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival. Plants 2021, 10, 286. https://doi.org/10.3390/plants10020286

AMA Style

Marrano N, Spagnuolo R, Biondi G, Cignarelli A, Perrini S, Vincenti L, Laviola L, Giorgino F, Natalicchio A. Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival. Plants. 2021; 10(2):286. https://doi.org/10.3390/plants10020286

Chicago/Turabian Style

Marrano, Nicola, Rosaria Spagnuolo, Giuseppina Biondi, Angelo Cignarelli, Sebastio Perrini, Leonardo Vincenti, Luigi Laviola, Francesco Giorgino, and Annalisa Natalicchio. 2021. "Effects of Extra Virgin Olive Oil Polyphenols on Beta-Cell Function and Survival" Plants 10, no. 2: 286. https://doi.org/10.3390/plants10020286

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