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Article

Artemisia annua Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles

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Faculty of Physics, West University of Timisoara, Blvd. V. Parvan 4, 300223 Timisoara, Romania
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Faculty of Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, 2 P-ta E. Murgu, 300041 Timisoara, Romania
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Faculty of Industrial Chemistry and Environmental Engineering, Polytechnic University Timisoara, 2 P-ta Victoriei, 300006 Timisoara, Romania
*
Author to whom correspondence should be addressed.
Academic Editors: Ivayla N. Dincheva, Ilian Badjakov and Bistra Galunska
Plants 2021, 10(11), 2245; https://doi.org/10.3390/plants10112245
Received: 18 September 2021 / Revised: 13 October 2021 / Accepted: 13 October 2021 / Published: 21 October 2021
The metabolites profile of a plant is greatly influenced by geographical factors and the ecological environment. Various studies focused on artemisinin and its derivates for their antiparasitic and antitumoral effects. However, after the isolation and purification stage, their pharmaceutical potential is limited due to their low bioavailability, permeability and lifetime. The antibacterial activity of essential oils has been another topic of interest for many studies on this plant. Nevertheless, only a few studies investigate other metabolites in Artemisia annua. Considering that secondary metabolites act synergistically in a plant, the existence of other metabolites with antitumor and high immunomodulating activity is even more important. Novel nano-carrier systems obtained by loading herbs into magnetic nanoparticles ensures the increase in the antitumor effect, but also, overcoming the barriers related to permeability, localization. This study reported the first complete metabolic profile from wild grown Romanian Artemisia annua. A total of 103 metabolites were identified under mass spectra (MS) positive mode from 13 secondary metabolite categories: amino acids, terpenoids, steroids, coumarins, flavonoids, organic acids, fatty acids, phenolic acids, carbohydrates, glycosides, aldehydes, hydrocarbons, etc. In addition, the biological activity of each class of metabolites was discussed. We further developed a simple and inexpensive nano-carrier system with the intention to capitalize on the beneficial properties of both components. Evaluation of the nano-carrier system’s morpho-structural and magnetic properties was performed. View Full-Text
Keywords: secondary metabolites; GC-MS; mass-spectra; bioactive compounds; nano-carrier system; magnetic nanoparticles secondary metabolites; GC-MS; mass-spectra; bioactive compounds; nano-carrier system; magnetic nanoparticles
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MDPI and ACS Style

Segneanu, A.-E.; Marin, C.N.; Ghirlea, I.O.-F.; Feier, C.V.I.; Muntean, C.; Grozescu, I. Artemisia annua Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles. Plants 2021, 10, 2245. https://doi.org/10.3390/plants10112245

AMA Style

Segneanu A-E, Marin CN, Ghirlea IO-F, Feier CVI, Muntean C, Grozescu I. Artemisia annua Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles. Plants. 2021; 10(11):2245. https://doi.org/10.3390/plants10112245

Chicago/Turabian Style

Segneanu, Adina-Elena, Catalin N. Marin, Ioan O.-F. Ghirlea, Catalin V.I. Feier, Cornelia Muntean, and Ioan Grozescu. 2021. "Artemisia annua Growing Wild in Romania—A Metabolite Profile Approach to Target a Drug Delivery System Based on Magnetite Nanoparticles" Plants 10, no. 11: 2245. https://doi.org/10.3390/plants10112245

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