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The Chromatin Remodeler LET-418/Mi2 is Required Cell Non-Autonomously for the Post-Embryonic Development of Caenorhabditis elegans

Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland
Author to whom correspondence should be addressed.
J. Dev. Biol. 2019, 7(1), 1;
Received: 15 November 2018 / Revised: 18 December 2018 / Accepted: 20 December 2018 / Published: 24 December 2018
(This article belongs to the Special Issue Caenorhabditis elegans - A Developmental Genetic Model System)
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Chromatin condition is crucial for the cells to respond to their environment. In C. elegans, post-embryonic development is accompanied by the exit of progenitor cells from quiescence in response to food. The chromatin protein LET-418/Mi2 is required for this transition in development indicating that proper chromatin structure in cells of the freshly hatched larvae is important to respond to food. However, the identity of the tissue or cells where LET-418/Mi2 is required, as well as the developmental signals that it is modulating have not been elucidated. By restoring the activity of LET-418/Mi2 in specific tissues, we demonstrate that its activity in the intestine and the hypodermis is able to promote in a cell non-autonomous manner the exit of blast cells from quiescence and further development. Furthermore, we identify the IIS (insulin/insulin-like growth factor signaling) pathway to be one of the signaling pathways that is conveying LET-418/Mi2 cell non-autonomous effect on development. View Full-Text
Keywords: chromatin; epigenetics; development; Caenorhabditis elegans chromatin; epigenetics; development; Caenorhabditis elegans

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Saudenova, M.; Wicky, C. The Chromatin Remodeler LET-418/Mi2 is Required Cell Non-Autonomously for the Post-Embryonic Development of Caenorhabditis elegans. J. Dev. Biol. 2019, 7, 1.

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