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The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning

by Hanna Shin 1 and David J. Reiner 1,2,*
1
Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, TX 77030, USA
2
College of Medicine, Texas A & M University, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
J. Dev. Biol. 2018, 6(4), 30; https://doi.org/10.3390/jdb6040030
Received: 15 November 2018 / Revised: 8 December 2018 / Accepted: 10 December 2018 / Published: 11 December 2018
(This article belongs to the Special Issue Caenorhabditis elegans - A Developmental Genetic Model System)
EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to assume a precise array of three cell fates with high fidelity. A group of core and modulatory signaling cascades forms a signaling network that demonstrates plasticity during the transition from naïve to terminally differentiated cells. In this review, we summarize the history of classical developmental manipulations and molecular genetics experiments that led to our understanding of the signals governing this process, and discuss principles of signal transduction and developmental biology that have emerged from these studies. View Full-Text
Keywords: EGF; EGFR; Ras; Notch; DSL; Raf; RalGEF; Ral; signal transduction; MAP kinase EGF; EGFR; Ras; Notch; DSL; Raf; RalGEF; Ral; signal transduction; MAP kinase
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Shin, H.; Reiner, D.J. The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning. J. Dev. Biol. 2018, 6, 30.

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