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Engineering the Drosophila Genome for Developmental Biology

Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
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J. Dev. Biol. 2017, 5(4), 16; https://doi.org/10.3390/jdb5040016
Received: 30 October 2017 / Revised: 7 December 2017 / Accepted: 8 December 2017 / Published: 11 December 2017
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous genomic loci facilitate imaging or biochemistry approaches at the cellular or subcellular levels. Similarly, the ability to make specific alterations to the genome sequence allows much more precise genetic control to address questions of gene function. View Full-Text
Keywords: Drosophila; genome engineering; CRISPR-Cas9; protein tagging Drosophila; genome engineering; CRISPR-Cas9; protein tagging
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Korona, D.; Koestler, S.A.; Russell, S. Engineering the Drosophila Genome for Developmental Biology. J. Dev. Biol. 2017, 5, 16.

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