Next Article in Journal
The Role of Hedgehog Signalling in the Formation of the Ventricular Septum
Next Article in Special Issue
Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems
Previous Article in Journal / Special Issue
Drosophila as a Model to Study the Link between Metabolism and Cancer
Article Menu

Export Article

Open AccessReview
J. Dev. Biol. 2017, 5(4), 16; https://doi.org/10.3390/jdb5040016

Engineering the Drosophila Genome for Developmental Biology

Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK
*
Author to whom correspondence should be addressed.
Received: 30 October 2017 / Revised: 7 December 2017 / Accepted: 8 December 2017 / Published: 11 December 2017
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
Full-Text   |   PDF [1434 KB, uploaded 11 December 2017]   |  

Abstract

The recent development of transposon and CRISPR-Cas9-based tools for manipulating the fly genome in vivo promises tremendous progress in our ability to study developmental processes. Tools for introducing tags into genes at their endogenous genomic loci facilitate imaging or biochemistry approaches at the cellular or subcellular levels. Similarly, the ability to make specific alterations to the genome sequence allows much more precise genetic control to address questions of gene function. View Full-Text
Keywords: Drosophila; genome engineering; CRISPR-Cas9; protein tagging Drosophila; genome engineering; CRISPR-Cas9; protein tagging
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Korona, D.; Koestler, S.A.; Russell, S. Engineering the Drosophila Genome for Developmental Biology. J. Dev. Biol. 2017, 5, 16.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
J. Dev. Biol. EISSN 2221-3759 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top