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Introduction: Drosophila—A Model System for Developmental Biology
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Drosophila as a Model to Study the Link between Metabolism and Cancer

Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 N Copenhagen, Denmark
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J. Dev. Biol. 2017, 5(4), 15; https://doi.org/10.3390/jdb5040015
Received: 10 November 2017 / Revised: 27 November 2017 / Accepted: 30 November 2017 / Published: 1 December 2017
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer. View Full-Text
Keywords: Drosophila; animal model; metabolism; cancer; Warburg effect; obesity; type 2 diabetes Drosophila; animal model; metabolism; cancer; Warburg effect; obesity; type 2 diabetes
MDPI and ACS Style

Herranz, H.; Cohen, S.M. Drosophila as a Model to Study the Link between Metabolism and Cancer. J. Dev. Biol. 2017, 5, 15.

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