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J. Dev. Biol. 2017, 5(4), 15; https://doi.org/10.3390/jdb5040015

Drosophila as a Model to Study the Link between Metabolism and Cancer

Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3, 2200 N Copenhagen, Denmark
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Received: 10 November 2017 / Revised: 27 November 2017 / Accepted: 30 November 2017 / Published: 1 December 2017
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
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Abstract

Cellular metabolism has recently been recognized as a hallmark of cancer. Investigating the origin and effects of the reprogrammed metabolism of tumor cells, and identifying its genetic mediators, will improve our understanding of how these changes contribute to disease progression and may suggest new approaches to therapy. Drosophila melanogaster is emerging as a valuable model to study multiple aspects of tumor formation and malignant transformation. In this review, we discuss the use of Drosophila as model to study how changes in cellular metabolism, as well as metabolic disease, contribute to cancer. View Full-Text
Keywords: Drosophila; animal model; metabolism; cancer; Warburg effect; obesity; type 2 diabetes Drosophila; animal model; metabolism; cancer; Warburg effect; obesity; type 2 diabetes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Herranz, H.; Cohen, S.M. Drosophila as a Model to Study the Link between Metabolism and Cancer. J. Dev. Biol. 2017, 5, 15.

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