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J. Dev. Biol. 2018, 6(1), 1; https://doi.org/10.3390/jdb6010001

Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems

1
Yale NUS College, 16 College Avenue West, Singapore 138610, Singapore
2
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 137673, Singapore
*
Author to whom correspondence should be addressed.
Received: 22 November 2017 / Revised: 19 December 2017 / Accepted: 21 December 2017 / Published: 22 December 2017
(This article belongs to the Special Issue Drosophila - A Model System for Developmental Biology)
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Abstract

Modeling human disease in animals is an important strategy to discover potential methods of intervention. We suggest that there is much to be gained by employing a multi-model approach that takes advantage of different animal systems used in the laboratory simultaneously. We use the example of modeling Alzheimer’s disease in Drosophila melanogaster, Caenorhabditis elegans, and Danio rerio to illustrate how such an approach can be employed to investigate the pathophysiology of the disease. View Full-Text
Keywords: Alzheimer’s disease; CRY2; Drosophila melanogaster; Caenorhabditis elegans; Danio rerio; optogenetics Alzheimer’s disease; CRY2; Drosophila melanogaster; Caenorhabditis elegans; Danio rerio; optogenetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Lim, C.H.; Mathuru, A.S. Modeling Alzheimer’s and Other Age Related Human Diseases in Embryonic Systems. J. Dev. Biol. 2018, 6, 1.

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