HLA-G Polymorphisms Are Associated with Non-Segmental Vitiligo among Brazilians
Abstract
:1. Introduction
2. Material and Methods
2.1. Population Sample
2.2. Extended HLA-G Analysis
2.3. Bioinformatics Analysis
2.4. Population Structure and Association Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Conflicts of Interest
References
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Variant | HLA-G Position | Associated Allele | Model | OR | L95 | U95 | P | Known HLA-G Alleles or Haplotypes |
---|---|---|---|---|---|---|---|---|
Before ancestry adjustment | ||||||||
rs9380142 | 3187 | G | Dominant | 2.096 | 1.145 | 3.838 | 0.0164 | Distal-010101a, Proximal-010101a, G*01:01:01:01, UTR-1 * |
After ancestry adjustment | ||||||||
rs9380142 | 3187 | G | Additive | 1.590 | 1.020 | 2.479 | 0.0404 | Distal-010101a, Proximal-010101a, G*01:01:01:01, UTR-1 * |
rs9380142 | 3187 | G | Dominant | 2.270 | 1.222 | 4.217 | 0.0095 | Distal-010101a, Proximal-010101a, G*01:01:01:01, UTR-1 * |
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Veiga-Castelli, L.; de Oliveira, M.L.; Pereira, A.; Debortoli, G.; Marcorin, L.; Fracasso, N.; Silva, G.; Souza, A.; Massaro, J.; Simões, A.L.; et al. HLA-G Polymorphisms Are Associated with Non-Segmental Vitiligo among Brazilians. Biomolecules 2019, 9, 463. https://doi.org/10.3390/biom9090463
Veiga-Castelli L, de Oliveira ML, Pereira A, Debortoli G, Marcorin L, Fracasso N, Silva G, Souza A, Massaro J, Simões AL, et al. HLA-G Polymorphisms Are Associated with Non-Segmental Vitiligo among Brazilians. Biomolecules. 2019; 9(9):463. https://doi.org/10.3390/biom9090463
Chicago/Turabian StyleVeiga-Castelli, Luciana, Maria Luiza de Oliveira, Alison Pereira, Guilherme Debortoli, Letícia Marcorin, Nádia Fracasso, Guilherme Silva, Andreia Souza, Juliana Massaro, Aguinaldo Luiz Simões, and et al. 2019. "HLA-G Polymorphisms Are Associated with Non-Segmental Vitiligo among Brazilians" Biomolecules 9, no. 9: 463. https://doi.org/10.3390/biom9090463