Next Article in Journal
The Therapeutic Potential of Nanoparticles to Reduce Inflammation in Atherosclerosis
Next Article in Special Issue
Variation in Chemical Composition and Biological Activities of Flos Chrysanthemi indici Essential Oil under Different Extraction Methods
Previous Article in Journal
The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and Its Mechanism: An Investigation Using Network Pharmacology-Based Analysis
Previous Article in Special Issue
The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology
Open AccessArticle

Polysaccharide Fraction Extracted from Endophytic Fungus Trichoderma atroviride D16 Has an Influence on the Proteomics Profile of the Salvia miltiorrhiza Hairy Roots

1
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China
2
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, No.1166 Liutai Avenue, Chengdu 611137, China
3
Department of Pharmacognosy, School of Pharmacy, Army Medical University, 30 Gaotanyan Street, Chongqing 400038, China
4
Faculty of Science, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
5
School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou 310053, China
*
Authors to whom correspondence should be addressed.
Authors contributed equally to this manuscript.
Biomolecules 2019, 9(9), 415; https://doi.org/10.3390/biom9090415
Received: 29 July 2019 / Revised: 15 August 2019 / Accepted: 20 August 2019 / Published: 26 August 2019
(This article belongs to the Special Issue Phytochemical Omics in Medicinal Plants)
Trichoderma atroviride develops a symbiont relationship with Salvia miltiorrhiza and this association involves a number of signaling pathways and proteomic responses between both partners. In our previous study, we have reported that polysaccharide fraction (PSF) of T. atroviride could promote tanshinones accumulation in S. miltiorrhiza hairy roots. Consequently, the present data elucidates the broad proteomics changes under treatment of PSF. Furthermore, we reported several previously undescribed and unexpected responses, containing gene expression patterns consistent with biochemical stresses and metabolic patterns inside the host. In summary, the PSF-induced tanshinones accumulation in S. miltiorrhiza hairy roots may be closely related to Ca2+ triggering, peroxide reaction, protein phosphorylation, and jasmonic acid (JA) signal transduction, leading to an increase in leucine-rich repeat (LRR) protein synthesis. This results in the changes in basic metabolic flux of sugars, amino acids, and protein synthesis, along with signal defense reactions. The results reported here increase our understanding of the interaction between T. atroviride and S. miltiorrhiza and specifically confirm the proteomic responses underlying the activities of PSF. View Full-Text
Keywords: polysaccharide fraction; Trichoderma atroviride; Salvia miltiorrhiza; proteomics; tanshinones polysaccharide fraction; Trichoderma atroviride; Salvia miltiorrhiza; proteomics; tanshinones
Show Figures

Figure 1

MDPI and ACS Style

Peng, W.; Ming, Q.-L.; Zhai, X.; Zhang, Q.; Rahman, K.; Wu, S.-J.; Qin, L.-P.; Han, T. Polysaccharide Fraction Extracted from Endophytic Fungus Trichoderma atroviride D16 Has an Influence on the Proteomics Profile of the Salvia miltiorrhiza Hairy Roots. Biomolecules 2019, 9, 415.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop