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Review

Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis

1
Laboratorio de Comunicaciones Celulares, Centro de estudios en Ejercicio, Metabolismo y Cáncer (CEMC), Programa de Biología Celular y Molecular, Facultad de Medicina, Universidad de Chile, Santiago 8380453, Chile
2
Centro Avanzado para Estudios en Enfermedades Crónicas (ACCDIS), Santiago 8380453, Chile
3
Centro de Medicina Regenerativa, Facultad de Medicina, Universidad del Desarrollo-Clínica Alemana, Santiago 7590943, Chile
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(8), 314; https://doi.org/10.3390/biom9080314
Received: 14 June 2019 / Revised: 17 July 2019 / Accepted: 25 July 2019 / Published: 29 July 2019
Caveolin-1 (CAV1) is a scaffolding protein with a controversial role in cancer. This review will initially discuss earlier studies focused on the role as a tumor suppressor before elaborating subsequently on those relating to function of the protein as a promoter of metastasis. Different mechanisms are summarized illustrating how CAV1 promotes such traits upon expression in cancer cells (intrinsic mechanisms). More recently, it has become apparent that CAV1 is also a secreted protein that can be included into exosomes where it plays a significant role in determining cargo composition. Thus, we will also discuss how CAV1 containing exosomes from metastatic cells promote malignant traits in more benign recipient cells (extrinsic mechanisms). This ability appears, at least in part, attributable to the transfer of specific cargos present due to CAV1 rather than the transfer of CAV1 itself. The evolution of how our perception of CAV1 function has changed since its discovery is summarized graphically in a time line figure.
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Keywords: caveolae; cholesterol transport; tumor suppressor; metastasis promoter; exosomes caveolae; cholesterol transport; tumor suppressor; metastasis promoter; exosomes
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MDPI and ACS Style

Campos, A.; Burgos-Ravanal, R.; González, M.F.; Huilcaman, R.; Lobos González, L.; Quest, A.F.G. Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis. Biomolecules 2019, 9, 314. https://doi.org/10.3390/biom9080314

AMA Style

Campos A, Burgos-Ravanal R, González MF, Huilcaman R, Lobos González L, Quest AFG. Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis. Biomolecules. 2019; 9(8):314. https://doi.org/10.3390/biom9080314

Chicago/Turabian Style

Campos, America, Renato Burgos-Ravanal, María F. González, Ricardo Huilcaman, Lorena Lobos González, and Andrew F.G. Quest 2019. "Cell Intrinsic and Extrinsic Mechanisms of Caveolin-1-Enhanced Metastasis" Biomolecules 9, no. 8: 314. https://doi.org/10.3390/biom9080314

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