Facile Preparation of Fe3O4/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan

Liu, Jun; Dong, Shuai; He, Quanguo; Yang, Suchun; Xie, Mei; Deng, Peihong; Xia, Yonghui; Li, Guangli

doi:10.3390/biom9060245

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Facile Preparation of Fe₃O₄/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan

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Hunan Key Laboratory of Biomedical Nanomaterials and Devices, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412007, China

Key Laboratory of Functional Metal-Organic Compounds of Hunan Province; Key Laboratory of functional Organometallic Materials of Hunan Provincial Universities; Department of Chemistry and Material Science, Hengyang Normal University, Hengyang 421008, China

Zhuzhou Institute for Food and Drug Control, Zhuzhou 412000, China

Authors to whom correspondence should be addressed.

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These authors contributed equally to this work.

Biomolecules 2019, 9(6), 245; https://doi.org/10.3390/biom9060245

Received: 30 May 2019 / Revised: 11 June 2019 / Accepted: 20 June 2019 / Published: 22 June 2019

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Abstract

In this study, we reported facile synthesis of Fe₃O₄/C composite and its application for the cost-effective and sensitive determination of tryptophan (Trp) in human serum samples. Fe₃O₄/C composites were prepared by a simple one-pot hydrothermal method followed by a mild calcination procedure, using FeCl₃∙6H₂O as Fe₃O₄ precursor, and glucose as reducing agent and carbon source simultaneously. The Fe₃O₄/C composite modified glassy carbon electrode (Fe₃O₄/C/GCE) was prepared by drop-casting method. The microstructure and morphology of Fe₃O₄/C composite was characterized by powder X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. Due to large specific surface area and synergistic effect from Fe₃O₄ nanoparticles and carbon coating, Fe₃O₄/C composite showed excellent electrocatalytic activity toward the oxidation of Trp. As a result, the proposed Fe₃O₄/C/GCE displayed superior analytical performances toward Trp determination, with two wide detection ranges (1.0–80 μM and 80–800 μM) and a low detection limit (0.26 μM, S/N = 3). Moreover, successful detection of Trp in human serum samples further validate the practicability of the proposed sensor. View Full-Text

Keywords: Fe₃O₄/C composite; tryptophan; voltammetric detection; second derivative linear scan voltammetry

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MDPI and ACS Style

Liu, J.; Dong, S.; He, Q.; Yang, S.; Xie, M.; Deng, P.; Xia, Y.; Li, G. Facile Preparation of Fe₃O₄/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan. Biomolecules 2019, 9, 245. https://doi.org/10.3390/biom9060245

AMA Style

Liu J, Dong S, He Q, Yang S, Xie M, Deng P, Xia Y, Li G. Facile Preparation of Fe₃O₄/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan. Biomolecules. 2019; 9(6):245. https://doi.org/10.3390/biom9060245

Chicago/Turabian Style

Liu, Jun, Shuai Dong, Quanguo He, Suchun Yang, Mei Xie, Peihong Deng, Yonghui Xia, and Guangli Li. 2019. "Facile Preparation of Fe₃O₄/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan" Biomolecules 9, no. 6: 245. https://doi.org/10.3390/biom9060245

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Facile Preparation of Fe₃O₄/C Nanocomposite and Its Application for Cost-Effective and Sensitive Detection of Tryptophan

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