Next Article in Journal
Alcohol Metabolism Potentiates HIV-Induced Hepatotoxicity: Contribution to End-Stage Liver Disease
Next Article in Special Issue
Oxidized LDL Modify the Human Adipocyte Phenotype to an Insulin Resistant, Proinflamatory and Proapoptotic Profile
Previous Article in Journal
Brassinosteroids Induce Strong, Dose-Dependent Inhibition of Etiolated Pea Seedling Growth Correlated with Ethylene Production
Previous Article in Special Issue
LCAT, ApoD, and ApoA1 Expression and Review of Cholesterol Deposition in the Cornea
Open AccessReview

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

by 1,†, 2,†, 1, 1,3,*, 1,* and 1,*
College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha 410128, Hunan, China
College of Life Sciences, Shandong Agricultural University, Tai’an 271018, Shandong, China
Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, CAS Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Changsha 410125, Hunan, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Biomolecules 2019, 9(12), 850;
Received: 14 November 2019 / Revised: 2 December 2019 / Accepted: 2 December 2019 / Published: 9 December 2019
The inflammasome is a multiprotein complex that acts to enhance inflammatory responses by promoting the production and secretion of key cytokines. The best-known inflammasome is the NLRP3 (nucleotide-binding oligomerization domain-like receptor [NLR] family pyrin domain-containing 3) inflammasome. The evidence has shown that the NLRP3 inflammasome, IL-1β, thioredoxin-interacting protein (TXNIP), and pyroptosis play vital roles in the development of diabetes. This review summarizes the regulation of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) by NLRP3 via modulation of glucose tolerance, insulin resistance, inflammation, and apoptosis mediated by endoplasmic reticulum stress in adipose tissue. Moreover, NLRP3 participates in intestinal homeostasis and inflammatory conditions, and NLRP3-deficient mice experience intestinal lesions. The diversity of an individual’s gut microbiome and the resultant microbial metabolites determines the extent of their involvement in the physiological and pathological mechanisms within the gut. As such, further study of the interaction between the NLRP3 inflammasome and the complex intestinal environment in disease development is warranted to discover novel therapies for the treatment of diabetes. View Full-Text
Keywords: diabetes; NLRP3; Glucose tolerance; insulin resistance; gut microbes diabetes; NLRP3; Glucose tolerance; insulin resistance; gut microbes
Show Figures

Figure 1

MDPI and ACS Style

Ding, S.; Xu, S.; Ma, Y.; Liu, G.; Jang, H.; Fang, J. Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes. Biomolecules 2019, 9, 850.

AMA Style

Ding S, Xu S, Ma Y, Liu G, Jang H, Fang J. Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes. Biomolecules. 2019; 9(12):850.

Chicago/Turabian Style

Ding, Sujuan; Xu, Sheng; Ma, Yong; Liu, Gang; Jang, Hongmei; Fang, Jun. 2019. "Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes" Biomolecules 9, no. 12: 850.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop