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Open AccessReview

Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics

1
Biophysics Unit, Department of Biochemistry and Molecular Biology, School of Medicine, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Catalonia, Spain
2
Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Pompeu Fabra University, 08003 Barcelona, Catalonia, Spain
3
Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallés, Catalonia, Spain
4
CIBER Cardiovascular Diseases (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain
5
REGICOR Study Group, Cardiovascular Epidemiology and Genetics Group, IMIM (Hospital Del Mar Medical Research Institute), 08003 Barcelona, Catalonia, Spain
6
Faculty of Medicine, University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain
*
Author to whom correspondence should be addressed.
Biomolecules 2019, 9(12), 791; https://doi.org/10.3390/biom9120791
Received: 14 October 2019 / Revised: 19 November 2019 / Accepted: 25 November 2019 / Published: 27 November 2019
Transient receptor potential cation channels are emerging as important physiological and therapeutic targets. Within the vanilloid subfamily, transient receptor potential vanilloid 2 (TRPV2) and 4 (TRPV4) are osmo- and mechanosensors becoming critical determinants in cell structure and activity. However, knowledge is scarce regarding how TRPV2 and TRPV4 are trafficked to the plasma membrane or specific organelles to undergo quality controls through processes such as biosynthesis, anterograde/retrograde trafficking, and recycling. This review lists and reviews a subset of protein–protein interactions from the TRPV2 and TRPV4 interactomes, which is related to trafficking processes such as lipid metabolism, phosphoinositide signaling, vesicle-mediated transport, and synaptic-related exocytosis. Identifying the protein and lipid players involved in trafficking will improve the knowledge on how these stretch-related channels reach specific cellular compartments. View Full-Text
Keywords: ion channel trafficking; transient receptor potential channels; TRPV2; TRPV4; phosphatidylinositol signaling; stretch-related channels ion channel trafficking; transient receptor potential channels; TRPV2; TRPV4; phosphatidylinositol signaling; stretch-related channels
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MDPI and ACS Style

Doñate-Macián, P.; Enrich-Bengoa, J.; Dégano, I.R.; Quintana, D.G.; Perálvarez-Marín, A. Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics. Biomolecules 2019, 9, 791.

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