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Open AccessReview

Strategy for the Biosynthesis of Short Oligopeptides: Green and Sustainable Chemistry

School of Biological Science, Jining Medical University, Jining 272000, China
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Authors to whom correspondence should be addressed.
These authors contributed equally to this manuscript.
Biomolecules 2019, 9(11), 733; https://doi.org/10.3390/biom9110733
Received: 1 October 2019 / Revised: 5 November 2019 / Accepted: 7 November 2019 / Published: 13 November 2019
Short oligopeptides are some of the most promising and functionally important amide bond-containing components, with widespread applications. Biosynthesis of these oligopeptides may potentially become the ultimate strategy because it has better cost efficiency and environmental-friendliness than conventional solid phase peptide synthesis and chemo-enzymatic synthesis. To successfully apply this strategy for the biosynthesis of structurally diverse amide bond-containing components, the identification and selection of specific biocatalysts is extremely important. Given that perspective, this review focuses on the current knowledge about the typical enzymes that might be potentially used for the synthesis of short oligopeptides. Moreover, novel enzymatic methods of producing desired peptides via metabolic engineering are highlighted. It is believed that this review will be helpful for technological innovation in the production of desired peptides. View Full-Text
Keywords: short oligopeptides; biosynthesis; non-ribosomal peptide synthesis; ATP-grasp enzyme; β-lactam; cyclic dipeptides; metabolic engineering short oligopeptides; biosynthesis; non-ribosomal peptide synthesis; ATP-grasp enzyme; β-lactam; cyclic dipeptides; metabolic engineering
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MDPI and ACS Style

Wang, T.; Zhang, Y.-R.; Liu, X.-H.; Ge, S.; Zhu, Y.-S. Strategy for the Biosynthesis of Short Oligopeptides: Green and Sustainable Chemistry. Biomolecules 2019, 9, 733.

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