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Biomolecules
Volume 9
Issue 10
10.3390/biom9100570
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Review

The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis

by
Jiarong Feng
1,†,
Yudi Chen
1,†,
Wenxi Hua
2,†,
Xiaohan Sun
1,†,
Yanjie Chen
1,
Yu Liu
1,
Jiaying Fan
3,
Yuening Zhao
2,
Lixiang Zhao
4,*,
Xiaojing Xu
5,* and
Xiaoqin Yang
1,*
1
Department of Bioinformatics, School of Biology and Basic Medical Sciences, Soochow University, 199 Ren’ai Road, Suzhou 215123, China
2
Medical College, Soochow University, 199 Ren’ai Road, Suzhou 215123, China
3
Department of Biotechnology, School of Biology and Basic Medical Sciences, Soochow University, 199 Ren’ai Road, Suzhou 215123, China
4
Department of Immunology, School of Biology and Basic Medical Sciences, Soochow University, 199 Ren’ai Road, Suzhou 215123, China
5
Department of Cell Biology, School of Biology and Basic Medical Sciences, Soochow University, 199 Ren’ai Road, Suzhou 215123, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2019, 9(10), 570; https://doi.org/10.3390/biom9100570
Received: 23 August 2019 / Revised: 30 September 2019 / Accepted: 2 October 2019 / Published: 4 October 2019
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Abstract

This meta-analysis aimed to systematically review the evidence on cancer risk of the MMP-8 rs11225395 promoter polymorphism. Relevant studies published by 12 June 2019 were identified by systematically searching PubMed, Web of Science, Cochrane Library, CNKI and Wanfang databases. R programs and STATA software were used to calculate odds ratio (OR) and 95% confidence interval (CI). In total, 7375 cancer samples and 8117 controls were included by integrating 15 case-control data sets. Pooled estimates from the statistical analysis revealed no statistical significance for the association between this polymorphism and cancer risk. All pooled estimates resulting from subgroup analyses by cancer type and sample size were not materially altered and did not draw significantly different conclusions. The stratified analyses according to geographic region showed the statistical significance for increased cancer risk of the MMP-8 rs11225395 polymorphism in non-Asian populations under the allele model (OR = 1.11, 95% CI: 1.04–1.19), homozygote model (OR = 1.22, 95% CI: 1.05–1.41), heterozygote model (OR = 1.21, 95% CI: 1.07–1.36), and dominant model (OR = 1.21, 95% CI: 1.08–1.35). However, no statistical significance was detected in Asian populations. In conclusion, these findings suggested that the MMP-8 rs11225395 polymorphism is associated with elevated susceptibility to cancer in non-Asian populations. View Full-Text
Keywords: MMP-8; single-nucleotide polymorphism; cancer; meta-analysis MMP-8; single-nucleotide polymorphism; cancer; meta-analysis
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MDPI and ACS Style

Feng, J.; Chen, Y.; Hua, W.; Sun, X.; Chen, Y.; Liu, Y.; Fan, J.; Zhao, Y.; Zhao, L.; Xu, X.; Yang, X. The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis. Biomolecules 2019, 9, 570. https://doi.org/10.3390/biom9100570

AMA Style

Feng J, Chen Y, Hua W, Sun X, Chen Y, Liu Y, Fan J, Zhao Y, Zhao L, Xu X, Yang X. The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis. Biomolecules. 2019; 9(10):570. https://doi.org/10.3390/biom9100570

Chicago/Turabian Style

Feng, Jiarong, Yudi Chen, Wenxi Hua, Xiaohan Sun, Yanjie Chen, Yu Liu, Jiaying Fan, Yuening Zhao, Lixiang Zhao, Xiaojing Xu, and Xiaoqin Yang. 2019. "The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis" Biomolecules 9, no. 10: 570. https://doi.org/10.3390/biom9100570

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