The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Data Sources and Identification
2.2. Study Eligibility Evaluation and Data Extraction
2.3. Statistics Analysis
3. Results
3.1. Characteristics of Included Studies
3.2. Main Analysis Results
3.3. Publication Bias and Sensitivity Analysis
3.4. Between-Study Heterogeneity Analysis
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Author | Year | Country | Region | Cancer Type | Matching Criteria | Genotyping Methods | Case-Control | HWE (p) | NOS |
---|---|---|---|---|---|---|---|---|---|
Kubben | 2006 | Dutch | Europe | gastric cancer | NA | PCR-RFLP | 79-169 | 0.75 | 6 |
Qiu | 2008 | China | Asia | hepatocellular carcinoma | NA | PCR-RFLP | 417-480 | 0.22 | 2 |
Debniak | 2011 | UK | Europe | melanoma | Age, gender | TaqMan | 296-290 | 0.75 | 6 |
Hashim | 2012 | Malaysia | Asia | nasopharyngeal carcinoma | Age, gender | Microarray | 48-48 | NA | 6 |
Laxton | 2012 | UK | Europe | breast cancer | Age | TaqMan | 2172-2268 | 0.43 | 6 |
Laxton | 2012 | Poland | Europe | breast cancer | Age, gender | TaqMan | 297-303 | NA | 5 |
Srivastava | 2013 | India | Asia | bladder cancer | Age, gender | PCR-RFLP | 200-200 | 0.48 | 8 |
Arechavaleta | 2014 | Mexico | Latin America | ovarian cancer | NA | PCR-RFLP | 35-37 | 0.01 | 5 |
Wieczorek | 2014 | Poland | Europe | bladder cancer | NA | TaqMan | 241-199 | 0.70 | 5 |
Hung | 2017 | China | Asia | oral cancer | Age, gender | PCR-RFLP | 788-956 | <0.01 | 7 |
Pei | 2017 | China | Asia | leukemia | Age | PCR-RFLP | 266-266 | 0.14 | 7 |
Shen | 2017 | China | Asia | lung cancer | Age, gender | PCR-RFLP | 358-716 | <0.01 | 8 |
Hsiao | 2018 | China | Asia | breast cancer | Age, gender | PCR-RFLP | 1232-1232 | <0.01 | 6 |
Tsai | 2018 | China | Asia | bladder cancer | Age, gender | PCR-RFLP | 375-375 | 0.08 | 8 |
Wang | 2018 | China | Asia | breast cancer | NA | Mass spectrum | 571-578 | NA | 7 |
Author | Year | Country | Cancer | Control | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC | CT | TT | CC+CT | CT+TT | C | T | MAF | CC | CT | TT | CC+CT | CT+TT | C | T | MAF | ||||
Kubben | 2006 | Dutch | 19 | 46 | 14 | 65 | 60 | 84 | 74 | 0.47 | 55 | 81 | 33 | 136 | 114 | 191 | 147 | 0.43 | |
Qiu | 2008 | China | 140 | 196 | 81 | 336 | 277 | 476 | 358 | 0.43 | 184 | 216 | 80 | 400 | 296 | 584 | 376 | 0.39 | |
Debniak | 2011 | UK | 86 | 152 | 58 | 238 | 210 | 324 | 268 | 0.45 | 113 | 134 | 43 | 247 | 177 | 360 | 220 | 0.38 | |
Hashim | 2012 | Malaysia | NA | NA | 1 | 47 | NA | NA | NA | NA | NA | NA | 8 | 40 | NA | NA | NA | NA | |
Laxton | 2012 | UK | 628 | 1105 | 439 | 1733 | 1544 | 2361 | 1983 | 0.46 | 735 | 1096 | 437 | 1831 | 1533 | 2566 | 1970 | 0.43 | |
Laxton | 2012 | Poland | NA | NA | NA | NA | NA | 332 | 262 | 0.44 | NA | NA | NA | NA | NA | 348 | 258 | 0.43 | |
Srivastava | 2013 | India | 99 | 90 | 11 | 189 | 101 | 288 | 112 | 0.28 | 92 | 84 | 24 | 176 | 108 | 268 | 132 | 0.33 | |
Arechavaleta | 2014 | Mexico | 6 | 16 | 13 | 22 | 29 | 28 | 42 | 0.60 | 6 | 26 | 5 | 32 | 31 | 38 | 36 | 0.49 | |
Wieczorek | 2014 | Poland | 72 | 125 | 44 | 197 | 169 | 269 | 213 | 0.44 | 60 | 101 | 38 | 161 | 139 | 221 | 177 | 0.44 | |
Hung | 2017 | China | 414 | 284 | 90 | 698 | 374 | 1112 | 464 | 0.29 | 466 | 364 | 126 | 830 | 490 | 1296 | 616 | 0.32 | |
Pei | 2017 | China | 139 | 98 | 29 | 237 | 127 | 376 | 156 | 0.29 | 129 | 105 | 32 | 234 | 137 | 363 | 169 | 0.31 | |
Shen | 2017 | China | 188 | 130 | 40 | 318 | 170 | 506 | 210 | 0.29 | 351 | 273 | 92 | 624 | 365 | 975 | 457 | 0.32 | |
Hsiao | 2018 | China | 648 | 466 | 118 | 1114 | 584 | 1762 | 702 | 0.28 | 633 | 468 | 131 | 1101 | 599 | 1734 | 730 | 0.30 | |
Tsai | 2018 | China | 186 | 152 | 37 | 338 | 189 | 524 | 226 | 0.30 | 197 | 140 | 38 | 337 | 178 | 534 | 216 | 0.29 | |
Wang | 2018 | China | NA | NA | NA | NA | NA | 724 | 418 | 0.37 | NA | NA | NA | NA | NA | 769 | 387 | 0.33 |
Comparison | Allele Model (T vs. C) | Homozygote Model (TT vs. CC) | Heterozygote Model (CT vs. CC) | Dominant Model (CT+TT vs. CC) | Recessive Model (TT vs. CC+CT) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(Number of Study) | OR (95% CI) | p | ph | OR (95% CI) | p | ph | OR (95% CI) | p | ph | OR (95% CI) | p | ph | OR (95% CI) | p | ph | |
Overall (15) | 1.03(0.95,1.11) | 0.46 | 0.02 | 1.01(0.85,1.20) | 0.90 | 0.03 | 1.06(0.98,1.14) | 0.14 | 0.13 | 1.04(0.93,1.16) | 0.49 | 0.03 | 0.97(0.83,1.13) | 0.70 | 0.05 | |
Region | ||||||||||||||||
Asia (9) | 0.97(0.89,1.07) | 0.57 | 0.07 | 0.89(0.77,1.03) | 0.12 | 0.18 | 0.97(0.88,1.07) | 0.55 | 0.57 | 0.95(0.87,1.04) | 0.26 | 0.34 | 0.89(0.77,1.02) | 0.09 | 0.14 | |
Others (6) | 1.11(1.04,1.19) | <0.01 | 0.43 | 1.22(1.05,1.41) | 0.01 | 0.39 | 1.21(1.07,1.36) | <0.01 | 0.43 | 1.21(1.08,1.35) | <0.01 | 0.45 | 1.09(0.96,1.24) | 0.19 | 0.17 | |
Cancer type | ||||||||||||||||
Bladder (3) | 0.97(0.83,1.12) | 0.67 | 0.29 | 0.85(0.61,1.17) | 0.32 | 0.14 | 1.08(0.87,1.33) | 0.49 | 0.84 | 1.02(0.84,1.25) | 0.81 | 0.58 | 0.83(0.61,1.12) | 0.22 | 0.15 | |
Breast (4) | 1.06(1.00,1.13) | 0.07 | 0.20 | 1.04(0.78,1.37) | 0.80 | 0.08 | 1.08(0.89,1.30) | 0.43 | 0.08 | 1.07(0.86,1.31) | 0.55 | 0.04 | 1.02(0.89,1.16) | 0.79 | 0.25 | |
Digestive System (3) | 1.03(0.83,1.28) | 0.78 | 0.05 | 0.99(0.79,1.24) | 0.95 | 0.11 | 1.10(0.80,1.49) | 0.57 | 0.07 | 1.09(0.79,1.51) | 0.59 | 0.04 | 0.97(0.79,1.20) | 0.80 | 0.30 | |
Others (5) | 1.07(0.83,1.39) | 0.60 | 0.02 | 1.14(0.71,1.86) | 0.58 | 0.05 | 1.01(0.74,1.37) | 0.96 | 0.09 | 1.03(0.75,1.44) | 0.84 | 0.04 | 1.08(0.65,1.79) | 0.78 | 0.02 | |
Sample Size | ||||||||||||||||
≤500 (5) | 0.98(0.82,1.16) | 0.80 | 0.20 | 0.87(0.60,1.27) | 0.48 | 0.11 | 1.08(0.83,1.41) | 0.56 | 0.46 | 1.02(0.79,1.31) | 0.88 | 0.51 | 0.82(0.41,1.64) | 0.57 | <0.01 | |
>500 (10) | 1.03(0.95,1.12) | 0.41 | 0.01 | 1.03(0.87,1.23) | 0.71 | 0.04 | 1.05(0.93,1.18) | 0.43 | 0.06 | 1.04(0.92,1.19) | 0.52 | <0.01 | 1.01(0.91,1.11) | 0.86 | 0.44 |
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Feng, J.; Chen, Y.; Hua, W.; Sun, X.; Chen, Y.; Liu, Y.; Fan, J.; Zhao, Y.; Zhao, L.; Xu, X.; et al. The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis. Biomolecules 2019, 9, 570. https://doi.org/10.3390/biom9100570
Feng J, Chen Y, Hua W, Sun X, Chen Y, Liu Y, Fan J, Zhao Y, Zhao L, Xu X, et al. The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis. Biomolecules. 2019; 9(10):570. https://doi.org/10.3390/biom9100570
Chicago/Turabian StyleFeng, Jiarong, Yudi Chen, Wenxi Hua, Xiaohan Sun, Yanjie Chen, Yu Liu, Jiaying Fan, Yuening Zhao, Lixiang Zhao, Xiaojing Xu, and et al. 2019. "The MMP-8 rs11225395 Promoter Polymorphism Increases Cancer Risk of Non-Asian Populations: Evidence from a Meta-Analysis" Biomolecules 9, no. 10: 570. https://doi.org/10.3390/biom9100570