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Biomolecules 2019, 9(1), 1; https://doi.org/10.3390/biom9010001

Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation

1
Medical Sciences Program, Indiana University, Bloomington, IN 47405, USA
2
Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN 47405, USA
Current address: Department of Biology, Franklin College, Franklin, IN 46131, USA.
*
Author to whom correspondence should be addressed.
Received: 29 November 2018 / Revised: 15 December 2018 / Accepted: 17 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Cytoskeleton and Regulation of Mitosis)
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Abstract

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular processes, including mitotic spindle assembly and chromosome segregation. There are a multitude of cellular factors that regulate the dynamicity of MTs and play critical roles in mitosis. Members of the Kinesin-8 family of motor proteins act as MT-destabilizing factors to control MT length in a spatially and temporally regulated manner. In this review, we focus on recent advances in our understanding of the structure and function of the Kinesin-8 motor domain, and the emerging contributions of the C-terminal tail of Kinesin-8 proteins to regulate motor activity and localization. View Full-Text
Keywords: microtubule dynamics; mitosis; spindle; molecular motor protein microtubule dynamics; mitosis; spindle; molecular motor protein
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Shrestha, S.; Hazelbaker, M.; Yount, A.L.; Walczak, C.E. Emerging Insights into the Function of Kinesin-8 Proteins in Microtubule Length Regulation. Biomolecules 2019, 9, 1.

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