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2′-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation?

Univ Lyon, Université Claude Bernard Lyon 1, INSERM U1052, CNRS UMR5286, Cancer Research Center of Lyon, 69008 Lyon, France
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Biomolecules 2018, 8(4), 106; https://doi.org/10.3390/biom8040106
Received: 17 August 2018 / Revised: 27 September 2018 / Accepted: 27 September 2018 / Published: 3 October 2018
(This article belongs to the Special Issue rRNA Biology)
Ribosomal RNA (rRNA) undergoes post-transcriptional modification of over 200 nucleotides, predominantly 2′-O-methylation (2′-O-Me). 2′-O-Methylation protects RNA from hydrolysis and modifies RNA strand flexibility but does not contribute to Watson-Crick base pairing. The contribution of 2′-O-Me to the translational capacity of ribosomes has been established. Yet, how 2′-O-Me participates in ribosome biogenesis and ribosome functioning remains unclear. The development of 2′-O-Me quantitative mapping methods has contributed to the demonstration that these modifications are not constitutive but rather provide heterogeneity to the ribosomal population. Moreover, recent advances in ribosome structure analysis and in vitro translation assays have proven, for the first time, that 2′-O-Me contributes to regulating protein synthesis. This review highlights the recent data exploring the impact of 2′-O-Me on ribosome structure and function, and the emerging idea that the rRNA epitranscriptome is involved in translational control. View Full-Text
Keywords: 2′-O-methylation; ribosomal RNA; fibrillarin; snoRNP; ribosome heterogeneity; mRNA translation 2′-O-methylation; ribosomal RNA; fibrillarin; snoRNP; ribosome heterogeneity; mRNA translation
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Monaco, P.L.; Marcel, V.; Diaz, J.-J.; Catez, F. 2′-O-Methylation of Ribosomal RNA: Towards an Epitranscriptomic Control of Translation? Biomolecules 2018, 8, 106.

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