Mucin-Type O-Glycosylation in Gastric Carcinogenesis
by
Henrique O. Duarte 1,2,3,†
, Daniela Freitas 1,2,3,†, Catarina Gomes 1,2, Joana Gomes 1,2, Ana Magalhães 1,2 and Celso A. Reis 1,2,3,4,*
Henrique O. Duarte 1,2,3,†, Daniela Freitas 1,2,3,†, Catarina Gomes 1,2, Joana Gomes 1,2, Ana Magalhães 1,2 and Celso A. Reis 1,2,3,4,*
1
i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Júlio Amaral de Carvalho, 45, Porto 4200-135, Portugal
2
Institute of Molecular Pathology and Immunology of University of Porto, Ipatimup, Rua Júlio Amaral de Carvalho, 45, Porto 4200-135, Portugal
3
Instituto de Ciências Biomédicas de Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira no. 228, Porto 4050-313, Portugal
4
Medical Faculty, University of Porto, Alameda Prof Hernâni Monteiro, Porto 4200-319, Portugal
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Academic Editor: Franz-Georg Hanisch
Biomolecules 2016, 6(3), 33; https://doi.org/10.3390/biom6030033
Received: 2 May 2016 / Revised: 1 July 2016 / Accepted: 4 July 2016 / Published: 11 July 2016
(This article belongs to the Special Issue Cancer and Glycosylation)
Mucin-type O-glycosylation plays a crucial role in several physiological and pathological processes of the gastric tissue. Modifications in enzymes responsible for key glycosylation steps and the consequent abnormal biosynthesis and expression of their glycan products constitute well-established molecular hallmarks of disease state. This review addresses the major role played by mucins and associated O-glycan structures in Helicobacter pylori adhesion to the gastric mucosa and the subsequent establishment of a chronic infection, with concomitant drastic alterations of the gastric epithelium glycophenotype. Furthermore, alterations of mucin expression pattern and glycan signatures occurring in preneoplastic lesions and in gastric carcinoma are also described, as well as their impact throughout the gastric carcinogenesis cascade and in cancer progression. Altogether, mucin-type O-glycosylation alterations may represent promising biomarkers with potential screening and prognostic applications, as well as predictors of cancer patients’ response to therapy.
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Keywords:
gastric cancer; mucins; O-glycosylation; glycosyltransferases; Helicobacter pylori; Lewis antigens
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Duarte, H.O.; Freitas, D.; Gomes, C.; Gomes, J.; Magalhães, A.; Reis, C.A. Mucin-Type O-Glycosylation in Gastric Carcinogenesis. Biomolecules 2016, 6, 33.
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