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Biocatalytic Synthesis of Chiral Alcohols and Amino Acids for Development of Pharmaceuticals

SLRP Associates Consultation in Biotechnology, 572 Cabot Hill Road, Bridgewater, NJ 08807, USA
Biomolecules 2013, 3(4), 741-777; https://doi.org/10.3390/biom3040741
Received: 23 August 2013 / Revised: 22 September 2013 / Accepted: 23 September 2013 / Published: 2 October 2013
(This article belongs to the Special Issue Enzymes and Their Biotechnological Applications)
Chirality is a key factor in the safety and efficacy of many drug products and thus the production of single enantiomers of drug intermediates and drugs has become increasingly important in the pharmaceutical industry. There has been an increasing awareness of the enormous potential of microorganisms and enzymes derived there from for the transformation of synthetic chemicals with high chemo-, regio- and enatioselectivities. In this article, biocatalytic processes are described for the synthesis of chiral alcohols and unntural aminoacids for pharmaceuticals. View Full-Text
Keywords: biocatalysis; enzymatic processes; chiral intermediates; drugs development biocatalysis; enzymatic processes; chiral intermediates; drugs development
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Patel, R.N. Biocatalytic Synthesis of Chiral Alcohols and Amino Acids for Development of Pharmaceuticals. Biomolecules 2013, 3, 741-777.

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