Altered Sphingolipid Metabolism in Patients with Metastatic Pancreatic Cancer
Abstract
:1. Introduction
2. Results and Discussion
2.1. Deregulation of Sphingolipid Metabolites in Patients with Pancreatic Cancer
Lipid | Pancreatitis | Nodal Negative | Nodal Positive |
---|---|---|---|
Sphingosine | 53.88 ± 27.55 | 43.96 ± 9.12 | 58.59 ± 10.29 |
Sphinganine | 6.48 ± 2.95 | 8.03 ± 3.27 | 11.57 ± 1.73 |
Sphingosine-1-phosphate | 2.15 ±1.72 | 1.19 ± 0.20 | 0.7918 ± 0.09 |
2.2. Deregulation of Growth Factors and Cytokines in Patients with Pancreatic Cancer
Cytokine/Growth Factor | Pancreatitis | Nodal Negative | Nodal Positive |
---|---|---|---|
CCL11 | 0.538 ± 0.078 | 0.714 ± 0.084 | 0.795 ± 0.042 * |
IFNγ | 0.944 ± 0.145 | 1.399 ± 0.184 | 1.196 ± 0.092 |
IL-6 | 0.204 ± 0.034 | 0.392 ± 0.055 * | 0.379 ± 0.049 * |
IL-8 | 0.320 ± 0.045 | 0.545 ± 0.066 * | 0.534 ± 0.047 * |
sFasL | 0.175 ± 0.026 | 0.226 ± 0.032 | 0.209 ± 0.017 |
VEGF | 0.933 ± 0.188 | 1.42 ± 0.159 | 1.339 ± 0.105 |
TNFα | 0.273 ± 0.044 | 0.470 ± 0.052 * | 0.366 ± 0.032 |
IP-10 | 0.846 ± 0.091 | 1.228 ± 0.187 | 1.772 ± 0.252 * |
3. Experimental Section
3.1. Pancreatic Cancer Clinical Specimen
3.2. Lipid Extraction and Mass Spectrometry Analysis of Tumor Specimen and Plasma
3.3. Cytokine Analysis
4. Conclusions
Acknowledgments
Conflict of Interest
References
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Jiang, Y.; DiVittore, N.A.; Young, M.M.; Jia, Z.; Xie, K.; Ritty, T.M.; Kester, M.; Fox, T.E. Altered Sphingolipid Metabolism in Patients with Metastatic Pancreatic Cancer. Biomolecules 2013, 3, 435-448. https://doi.org/10.3390/biom3030435
Jiang Y, DiVittore NA, Young MM, Jia Z, Xie K, Ritty TM, Kester M, Fox TE. Altered Sphingolipid Metabolism in Patients with Metastatic Pancreatic Cancer. Biomolecules. 2013; 3(3):435-448. https://doi.org/10.3390/biom3030435
Chicago/Turabian StyleJiang, Yixing, Nicole A. DiVittore, Megan M Young, Zhiliang Jia, Keping Xie, Timothy M. Ritty, Mark Kester, and Todd E. Fox. 2013. "Altered Sphingolipid Metabolism in Patients with Metastatic Pancreatic Cancer" Biomolecules 3, no. 3: 435-448. https://doi.org/10.3390/biom3030435