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Biomolecules
Volume 15
Issue 10
10.3390/biom15101400
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Review

Research Progress on Quinone Compounds for the Treatment of Hepatocellular Carcinoma

by
Yaowu Ye
1,
Mengmeng Liu
1,
Yukang Miao
2,
Ke Pei
1,
Zhe Lin
1,
Songyan Liu
3,
Xiaowei Huang
1,
Yuchen Wang
1,* and
Guangfu Lv
2,*
1
School Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun 130117, China
2
Jilin Province Ginseng Science Research Institute, Changchun University of Chinese Medicine, Changchun 130117, China
3
Changchun Institute of Anticancer Drugs, Changchun 130033, China
*
Authors to whom correspondence should be addressed.
Biomolecules 2025, 15(10), 1400; https://doi.org/10.3390/biom15101400
Submission received: 20 August 2025 / Revised: 24 September 2025 / Accepted: 29 September 2025 / Published: 1 October 2025
(This article belongs to the Section Natural and Bio-derived Molecules)
Versions Notes

Abstract

Hepatocellular carcinoma (HCC) is the third most common cancer worldwide, widely prevalent across many countries, and poses a serious threat to human health. With changes in its epidemiology, the incidence of HCC is expected to continue rising. As a class of organic molecules widely distributed in nature, quinone compounds possess notable antioxidant, antibacterial, and antitumor properties. This article selects several quinone compounds that have shown notable research progress in recent years and artificially categorizes them into “plant-derived quinone compounds” and “non-plant-derived quinone compounds.” We then provide a detailed review of the research findings regarding HCC in vitro and in vivo experiments and clinical trials, including their potential toxic side effects. Additionally, based on the varying toxicity reduction of several selected plant-derived quinones when combined with doxorubicin, we further hypothesize that these plant-derived quinone compounds may also exert detoxifying effects on other non-plant-derived quinones discussed in this article. In summary, quinone compounds still hold significant research value and development potential in the fight against HCC. At the same time, we hope our review will provide valuable insights and inspiration for future research in this field.
Keywords: hepatocellular carcinoma; quinone compounds; potential therapeutic strategies; medical application; bioactivity; pharmacological mechanism hepatocellular carcinoma; quinone compounds; potential therapeutic strategies; medical application; bioactivity; pharmacological mechanism

Share and Cite

MDPI and ACS Style

Ye, Y.; Liu, M.; Miao, Y.; Pei, K.; Lin, Z.; Liu, S.; Huang, X.; Wang, Y.; Lv, G. Research Progress on Quinone Compounds for the Treatment of Hepatocellular Carcinoma. Biomolecules 2025, 15, 1400. https://doi.org/10.3390/biom15101400

AMA Style

Ye Y, Liu M, Miao Y, Pei K, Lin Z, Liu S, Huang X, Wang Y, Lv G. Research Progress on Quinone Compounds for the Treatment of Hepatocellular Carcinoma. Biomolecules. 2025; 15(10):1400. https://doi.org/10.3390/biom15101400

Chicago/Turabian Style

Ye, Yaowu, Mengmeng Liu, Yukang Miao, Ke Pei, Zhe Lin, Songyan Liu, Xiaowei Huang, Yuchen Wang, and Guangfu Lv. 2025. "Research Progress on Quinone Compounds for the Treatment of Hepatocellular Carcinoma" Biomolecules 15, no. 10: 1400. https://doi.org/10.3390/biom15101400

APA Style

Ye, Y., Liu, M., Miao, Y., Pei, K., Lin, Z., Liu, S., Huang, X., Wang, Y., & Lv, G. (2025). Research Progress on Quinone Compounds for the Treatment of Hepatocellular Carcinoma. Biomolecules, 15(10), 1400. https://doi.org/10.3390/biom15101400

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