The Challenges and Prospects of p53-Based Therapies in Ovarian Cancer

Round 1

Reviewer 1 Report

This is an excellent review article that summarizes a wide range of p53-based therapies in ovarian cancer. 

* The title can be more specific, rather than "The role of...". For example, "The challenges and prospects of p53-based therapies in ovarian cancer". 

* Line 460, (new ref)? 

Author Response

The reviewer suggested “the title can be more specific, rather than ‘the role of…’ For example, “the challenges and prospects of p53-based therapies in ovarian cancer.” We appreciate the suggestion and have changed the title to “The challenges and prospects of p53-based therapies in ovarian cancer” as suggested.

The reviewer noted an editing error on line 460 that said: “(new ref).” This was part of our editing process and we inadvertently missed adding a reference here. The review has been edited to include the appropriate reference at this location.

As kindly highlighted by the reviewer, minor spell checks and grammatical changes were occasionally warranted. The document was edited for grammatical changes and updates can be found under the track changes tab.

Reviewer 2 Report

The review Ms entitled "The Role of p53-based therapies in ovarian cancer" addresses the main developments regarding P53 therapies in recent years. It is well organized and is based on a solid set of bibliographical references. Importantly, the reasons for the failure in the success of this type of therapy in the treatment of HGSOC, which contain a large percentage of mutations in the TP53 gene, are well addressed. The only suggestion is regarding Table 1 which should be edited (is large and the colors used make it hard to read).

Author Response

The reviewer indicated that “the only suggestion is regarding Table 1 which should be edited (is large and the colors used make it hard to read).” We appreciate the reviewer’s suggestion and have updated Table 1 accordingly. The colors have been lightened for easier reading. It should be noted that the colors correspond to the groupings and colors from Figure 1. To make the table smaller, we added the references to the first column thereby removing the last column. Furthermore, we resized columns to reduce the size. Finally, we aligned the text to the left for easier reading. We attempted to change the spacing to single space on the document but were unable to. We would request a change in the spacing to single space in Table 1 by the editor, if possible (but we understand it may be the journal style).

As highlighted by the reviewer, minor spell checks and grammatical changes were occasionally warranted. The document was edited for grammatical changes and updates can be found under the track changes tab.