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Volume 12
Issue 8
10.3390/biom12081152
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Review

STIM Proteins and Regulation of SOCE in ER-PM Junctions

by
Moaz Ahmad
†,
Sasirekha Narayanasamy
†,
Hwei Ling Ong
* and
Indu Ambudkar
*
Secretory Physiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Biomolecules 2022, 12(8), 1152; https://doi.org/10.3390/biom12081152
Submission received: 20 July 2022 / Revised: 12 August 2022 / Accepted: 15 August 2022 / Published: 20 August 2022
(This article belongs to the Special Issue Lipid-Gating and Lipid-Protein Interactions in Ion Channels)
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Abstract

ER-PM junctions are membrane contact sites formed by the endoplasmic reticulum (ER) and plasma membrane (PM) in close apposition together. The formation and stability of these junctions are dependent on constitutive and dynamic enrichment of proteins, which either contribute to junctional stability or modulate the lipid levels of both ER and plasma membranes. The ER-PM junctions have come under much scrutiny recently as they serve as hubs for assembling the Ca2+ signaling complexes. This review summarizes: (1) key findings that underlie the abilities of STIM proteins to accumulate in ER-PM junctions; (2) the modulation of Orai/STIM complexes by other components found within the same junction; and (3) how Orai1 channel activation is coordinated and coupled with downstream signaling pathways.
Keywords: ER-PM junctions; STIM; Orai1; phospholipids; calcium signaling; SOCE ER-PM junctions; STIM; Orai1; phospholipids; calcium signaling; SOCE

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MDPI and ACS Style

Ahmad, M.; Narayanasamy, S.; Ong, H.L.; Ambudkar, I. STIM Proteins and Regulation of SOCE in ER-PM Junctions. Biomolecules 2022, 12, 1152. https://doi.org/10.3390/biom12081152

AMA Style

Ahmad M, Narayanasamy S, Ong HL, Ambudkar I. STIM Proteins and Regulation of SOCE in ER-PM Junctions. Biomolecules. 2022; 12(8):1152. https://doi.org/10.3390/biom12081152

Chicago/Turabian Style

Ahmad, Moaz, Sasirekha Narayanasamy, Hwei Ling Ong, and Indu Ambudkar. 2022. "STIM Proteins and Regulation of SOCE in ER-PM Junctions" Biomolecules 12, no. 8: 1152. https://doi.org/10.3390/biom12081152

APA Style

Ahmad, M., Narayanasamy, S., Ong, H. L., & Ambudkar, I. (2022). STIM Proteins and Regulation of SOCE in ER-PM Junctions. Biomolecules, 12(8), 1152. https://doi.org/10.3390/biom12081152

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