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Biomolecules
Volume 12
Issue 7
10.3390/biom12070965
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Article

Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo

by
Yi Gong
1,
Haoyi Li
1,
Fei Wu
1,
Yishuai Li
1 and
Shicui Zhang
1,2,*
1
Department of Marine Biology, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China
2
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266003, China
*
Author to whom correspondence should be addressed.
Biomolecules 2022, 12(7), 965; https://doi.org/10.3390/biom12070965
Submission received: 9 June 2022 / Revised: 1 July 2022 / Accepted: 8 July 2022 / Published: 10 July 2022
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Abstract

With the increase in the incidence of fungal infections, and the restrictions of existing antifungal drugs, the development of novel antifungal agents is urgent. Here we prove that AP10W, a short peptide derived from AP-2 complex subunit mu-A, displays conspicuous antifungal activities against the main fungal pathogens of human infections Candida albicans and Aspergillus fumigatus. We also show that AP10W suppresses the fungal biofilm formation, and reduces the pre-established fungal biofilms. AP10W appears to exert its fungicidal activity through a mode of combined actions, including interaction with the fungal cell walls via laminarin, mannan and chitin, enhancement of cell wall permeabilization, induction of membrane depolarization, and increase in intracellular ROS generation. Importantly, we demonstrate that AP10W exhibits little toxicity towards mammalian fibroblasts, and effectively promotes the healing of wounded skins infected by C. albicans. These together indicate that AP10W is a new member of fungicidal agents. It also suggests that AP10W has a considerable potential for future development as a novel antifungal drug.
Keywords: antifungal peptide; wound healing; fungus; Candida albicans; Aspergillus fumigatus antifungal peptide; wound healing; fungus; Candida albicans; Aspergillus fumigatus

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MDPI and ACS Style

Gong, Y.; Li, H.; Wu, F.; Li, Y.; Zhang, S. Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo. Biomolecules 2022, 12, 965. https://doi.org/10.3390/biom12070965

AMA Style

Gong Y, Li H, Wu F, Li Y, Zhang S. Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo. Biomolecules. 2022; 12(7):965. https://doi.org/10.3390/biom12070965

Chicago/Turabian Style

Gong, Yi, Haoyi Li, Fei Wu, Yishuai Li, and Shicui Zhang. 2022. "Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo" Biomolecules 12, no. 7: 965. https://doi.org/10.3390/biom12070965

APA Style

Gong, Y., Li, H., Wu, F., Li, Y., & Zhang, S. (2022). Fungicidal Activity of AP10W, a Short Peptide Derived from AP-2 Complex Subunit mu-A, In Vitro and In Vivo. Biomolecules, 12(7), 965. https://doi.org/10.3390/biom12070965

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