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Biomolecules
Volume 12
Issue 3
10.3390/biom12030473
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Review

Evaluation of Adipose Cell-Based Therapies for the Treatment of Thumb Carpometacarpal Joint Osteoarthritis

by
Eleni Karagergou
1,*,
Theodora Ligomenou
1,
Byron Chalidis
2,
Dimitrios Kitridis
2,
Sophia Papadopoulou
1 and
Panagiotis Givissis
2
1
Department of Burns, Plastic Surgery and Hand Surgery, Georgios Papanikolaou Hospital, 57010 Thessaloniki, Greece
2
1st Orthopaedic Department, School of Medicine, Georgios Papanikolaou Hospital, Aristotle University of Thessaloniki, 57010 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Biomolecules 2022, 12(3), 473; https://doi.org/10.3390/biom12030473
Submission received: 30 January 2022 / Revised: 4 March 2022 / Accepted: 18 March 2022 / Published: 20 March 2022
(This article belongs to the Special Issue Core of Biomolecules Affecting Degenerative Disorders)
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Abstract

Adipose tissue and its regenerative products which are isolated with enzymatic or mechanical processing of the harvested fat have been studied in a wide range of degenerative diseases, including osteoarthritis of the knee and hip. Intra-articular injection of these products can provide symptomatic relief of pain and postpone surgery. However, their use in the treatment of thumb carpometacarpal joint (CMCJ) osteoarthritis is limited and just a few studies have been published on that topic. For this reason, a review of the literature was performed by a thorough search of eight terms using the Pubmed database. In total, seven human studies met the selection criteria, including case-control studies, case-series and one case report. In all studies, intra-articular injection of autologous fat in osteoarthritic thumb CMCJ provided reduction in pain and improvement in hand function. Grip and pinch strength showed variable results, from no change to significant improvement. Fat-processing techniques were based on centrifugation and mechanical homogenization but biological characterization of the injected cells was not performed in any study. Although the results are encouraging, a uniformly standardized method of fat processing and the conduction of randomized controlled trials in the future could better evaluate the effectiveness of this procedure for thumb CMCJ osteoarthritis.
Keywords: fat grafting; fat transfer; carpometacarpal arthritis; thumb arthritis fat grafting; fat transfer; carpometacarpal arthritis; thumb arthritis

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MDPI and ACS Style

Karagergou, E.; Ligomenou, T.; Chalidis, B.; Kitridis, D.; Papadopoulou, S.; Givissis, P. Evaluation of Adipose Cell-Based Therapies for the Treatment of Thumb Carpometacarpal Joint Osteoarthritis. Biomolecules 2022, 12, 473. https://doi.org/10.3390/biom12030473

AMA Style

Karagergou E, Ligomenou T, Chalidis B, Kitridis D, Papadopoulou S, Givissis P. Evaluation of Adipose Cell-Based Therapies for the Treatment of Thumb Carpometacarpal Joint Osteoarthritis. Biomolecules. 2022; 12(3):473. https://doi.org/10.3390/biom12030473

Chicago/Turabian Style

Karagergou, Eleni, Theodora Ligomenou, Byron Chalidis, Dimitrios Kitridis, Sophia Papadopoulou, and Panagiotis Givissis. 2022. "Evaluation of Adipose Cell-Based Therapies for the Treatment of Thumb Carpometacarpal Joint Osteoarthritis" Biomolecules 12, no. 3: 473. https://doi.org/10.3390/biom12030473

APA Style

Karagergou, E., Ligomenou, T., Chalidis, B., Kitridis, D., Papadopoulou, S., & Givissis, P. (2022). Evaluation of Adipose Cell-Based Therapies for the Treatment of Thumb Carpometacarpal Joint Osteoarthritis. Biomolecules, 12(3), 473. https://doi.org/10.3390/biom12030473

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