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Biomolecules
Volume 12
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10.3390/biom12010068
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Review

Role of Natural Killer Cells during Pregnancy and Related Complications

by
Deviyani Mahajan
1,
Neeta Raj Sharma
1,
Sudhakar Kancharla
2,
Prachetha Kolli
3,
Ashutosh Tripathy
1,
Amarish Kumar Sharma
1,
Sanjeev Singh
1,
Sudarshan Kumar
4,
Ashok Kumar Mohanty
5 and
Manoj Kumar Jena
1,*
1
Department of Biotechnology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, Punjab, India
2
Devansh Lab Werks, 234 Aquarius Drive, Homewood, AL 35209, USA
3
Microgen Health Inc., 14225 Sullyfield Cir Suite E, Chantilly, VA 20151, USA
4
Animal Biotechnology Centre, National Dairy Research Institute, Karnal 132001, Haryana, India
5
Indian Veterinary Research Institute, Mukteswar Campus, Mukteswar 263138, Uttarakhand, India
*
Author to whom correspondence should be addressed.
Biomolecules 2022, 12(1), 68; https://doi.org/10.3390/biom12010068
Submission received: 1 December 2021 / Revised: 28 December 2021 / Accepted: 1 January 2022 / Published: 4 January 2022
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Abstract

A high number of leucocytes reside in the human endometrium and are distributed differentially during the menstrual cycle and pregnancy. During early pregnancy, decidual natural killer (dNK) cells are the most common type of natural killer (NK) cells in the uterus. The increase in the number of uterine NK (uNK) cells during the mid-secretory phase of the menstrual cycle, followed by further increase of dNK cells in early pregnancy, has heightened interest in their involvement during pregnancy. Extensive research has revealed various roles of dNK cells during pregnancy including the formation of new blood vessels, migration of trophoblasts, and immunological tolerance. The present review article is focused on the significance of NK cells during pregnancy and their role in pregnancy-related diseases. The article will provide an in-depth review of cellular and molecular interactions during pregnancy and related disorders, with NK cells playing a pivotal role. Moreover, this study will help researchers to understand the physiology of normal pregnancy and related complications with respect to NK cells, so that future research work can be designed to alleviate the complications.
Keywords: naturalkiller cells; endometrium; pregnancy; decidual angiogenesis; preeclampsia naturalkiller cells; endometrium; pregnancy; decidual angiogenesis; preeclampsia

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MDPI and ACS Style

Mahajan, D.; Sharma, N.R.; Kancharla, S.; Kolli, P.; Tripathy, A.; Sharma, A.K.; Singh, S.; Kumar, S.; Mohanty, A.K.; Jena, M.K. Role of Natural Killer Cells during Pregnancy and Related Complications. Biomolecules 2022, 12, 68. https://doi.org/10.3390/biom12010068

AMA Style

Mahajan D, Sharma NR, Kancharla S, Kolli P, Tripathy A, Sharma AK, Singh S, Kumar S, Mohanty AK, Jena MK. Role of Natural Killer Cells during Pregnancy and Related Complications. Biomolecules. 2022; 12(1):68. https://doi.org/10.3390/biom12010068

Chicago/Turabian Style

Mahajan, Deviyani, Neeta Raj Sharma, Sudhakar Kancharla, Prachetha Kolli, Ashutosh Tripathy, Amarish Kumar Sharma, Sanjeev Singh, Sudarshan Kumar, Ashok Kumar Mohanty, and Manoj Kumar Jena. 2022. "Role of Natural Killer Cells during Pregnancy and Related Complications" Biomolecules 12, no. 1: 68. https://doi.org/10.3390/biom12010068

APA Style

Mahajan, D., Sharma, N. R., Kancharla, S., Kolli, P., Tripathy, A., Sharma, A. K., Singh, S., Kumar, S., Mohanty, A. K., & Jena, M. K. (2022). Role of Natural Killer Cells during Pregnancy and Related Complications. Biomolecules, 12(1), 68. https://doi.org/10.3390/biom12010068

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