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Epigenetic Alterations in Pancreatic Cancer Metastasis

by 1,2,†, 1,2,†, 1 and 1,2,3,*
Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California Davis, Davis, CA 95616, USA
Biochemistry, Molecular, Cellular and Developmental Biology Graduate Group, University of California Davis, Davis, CA 95616, USA
Comprehensive Cancer Center, University of California Davis, Sacramento, CA 95817, USA
Author to whom correspondence should be addressed.
Equal contribution.
Academic Editor: Gyeong Hoon Kang
Biomolecules 2021, 11(8), 1082;
Received: 23 June 2021 / Revised: 16 July 2021 / Accepted: 19 July 2021 / Published: 22 July 2021
(This article belongs to the Section Molecular Medicine)
Pancreatic cancer is the third leading cause of cancer-related deaths in the United States. Pancreatic ductal adenocarcinoma (PDA) is the most common (90%) and aggressive type of pancreatic cancer. Genomic analyses of PDA specimens have identified the recurrent genetic mutations that drive PDA initiation and progression. However, the underlying mechanisms that further drive PDA metastasis remain elusive. Despite many attempts, no recurrent genetic mutation driving PDA metastasis has been found, suggesting that PDA metastasis is driven by epigenetic fluctuations rather than genetic factors. Therefore, establishing epigenetic mechanisms of PDA metastasis would facilitate the development of successful therapeutic interventions. In this review, we provide a comprehensive overview on the role of epigenetic mechanisms in PDA as a critical contributor on PDA progression and metastasis. In particular, we explore the recent advancements elucidating the role of nucleosome remodeling, histone modification, and DNA methylation in the process of cancer metastasis. View Full-Text
Keywords: pancreatic cancer; epigenetics; metastasis; DNA methylation pancreatic cancer; epigenetics; metastasis; DNA methylation
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MDPI and ACS Style

Wang, S.S.; Xu, J.; Ji, K.Y.; Hwang, C.-I. Epigenetic Alterations in Pancreatic Cancer Metastasis. Biomolecules 2021, 11, 1082.

AMA Style

Wang SS, Xu J, Ji KY, Hwang C-I. Epigenetic Alterations in Pancreatic Cancer Metastasis. Biomolecules. 2021; 11(8):1082.

Chicago/Turabian Style

Wang, Sarah S., Jihao Xu, Keely Y. Ji, and Chang-Il Hwang. 2021. "Epigenetic Alterations in Pancreatic Cancer Metastasis" Biomolecules 11, no. 8: 1082.

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