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Challenges and Perspective in Integrated Multi-Omics in Gut Microbiota Studies
Article

A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats

1
Eurecat, Centre Tecnològic de Catalunya, Unitat de Nutrició i Salut, 43204 Reus, Spain
2
Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
3
Department of Biology, University of Turku, 20014 Turku, Finland
4
Eurecat, Centre Tecnològic de Catalunya, Centre for Omic Sciences (COS), Joint Unit Universitat Rovira i Virgili−EURECAT, 43204 Reus, Spain
5
Eurecat, Centre Tecnològic de Catalunya, eHealth Unit, 08005 Barcelona, Spain
6
Nutrigenomics Research Group, Department of Biochemistry and Biotechnology, Universitat Rovira i Virgili, 43007 Tarragona, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Jorge Joven
Biomolecules 2021, 11(2), 303; https://doi.org/10.3390/biom11020303
Received: 29 November 2020 / Revised: 6 February 2021 / Accepted: 13 February 2021 / Published: 18 February 2021
(This article belongs to the Special Issue Metabolomics and Integrated Multi-Omics in Health and Disease)
Obesity is one of the most incident and concerning disease worldwide. Definite strategies to prevent obesity and related complications remain elusive. Among the risk factors of the onset of obesity, gut microbiota might play an important role in the pathogenesis of the disease, and it has received extensive attention because it affects the host metabolism. In this study, we aimed to define a metabolic profile of the segregated obesity-associated gut dysbiosis risk factor. The study of the metabolome, in an obesity-associated gut dysbiosis model, provides a relevant way for the discrimination on the different biomarkers in the obesity onset. Thus, we developed a model of this obesity risk factors through the transference of gut microbiota from obese to non-obese male Wistar rats and performed a subsequent metabolic analysis in the receptor rats. Our results showed alterations in the lipid metabolism in plasma and in the phenylalanine metabolism in urine. In consequence, we have identified metabolic changes characterized by: (1) an increase in DG:34:2 in plasma, a decrease in hippurate, (2) an increase in 3-HPPA, and (3) an increase in o-coumaric acid. Hereby, we propose these metabolites as a metabolic profile associated to a segregated dysbiosis state related to obesity disease. View Full-Text
Keywords: microbial dysbiosis; gut microbiota; metagenomics; metabolomics; dysbiosis biomarkers; metabolic profile; diacylglycerol 34:2; hippurate; 3-HPPA; o-coumaric acid microbial dysbiosis; gut microbiota; metagenomics; metabolomics; dysbiosis biomarkers; metabolic profile; diacylglycerol 34:2; hippurate; 3-HPPA; o-coumaric acid
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MDPI and ACS Style

Hernandez-Baixauli, J.; Puigbò, P.; Torrell, H.; Palacios-Jordan, H.; Ripoll, V.J.R.; Caimari, A.; Del Bas, J.M.; Baselga-Escudero, L.; Mulero, M. A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats. Biomolecules 2021, 11, 303. https://doi.org/10.3390/biom11020303

AMA Style

Hernandez-Baixauli J, Puigbò P, Torrell H, Palacios-Jordan H, Ripoll VJR, Caimari A, Del Bas JM, Baselga-Escudero L, Mulero M. A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats. Biomolecules. 2021; 11(2):303. https://doi.org/10.3390/biom11020303

Chicago/Turabian Style

Hernandez-Baixauli, Julia, Pere Puigbò, Helena Torrell, Hector Palacios-Jordan, Vicent J.R. Ripoll, Antoni Caimari, Josep M. Del Bas, Laura Baselga-Escudero, and Miquel Mulero. 2021. "A Pilot Study for Metabolic Profiling of Obesity-Associated Microbial Gut Dysbiosis in Male Wistar Rats" Biomolecules 11, no. 2: 303. https://doi.org/10.3390/biom11020303

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