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Open AccessReview

Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review

1
Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt
2
Medical Plant Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Science, Shahrekord 88157-13471, Iran
3
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran
*
Author to whom correspondence should be addressed.
Academic Editor: Elena Leychenko
Biomolecules 2021, 11(2), 258; https://doi.org/10.3390/biom11020258
Received: 27 December 2020 / Revised: 1 February 2021 / Accepted: 2 February 2021 / Published: 10 February 2021
(This article belongs to the Special Issue Marine Natural Compounds with Biomedical Potential)
Marine sponges (porifera) have proved to be a prolific source of unique bioactive secondary metabolites, among which the alkaloids occupy a special place in terms of unprecedented structures and outstanding biological activities. Identification of active cytotoxic alkaloids extracted from marine animals, particularly sponges, is an important strive, due to lack of knowledge on traditional experiential and ethnopharmacology investigations. In this report, a comprehensive survey of demospongian bioactive alkaloids in the range 1987–2020 had been performed with a special emphasis on the potent cytotoxic activity. Different resources and databases had been investigated, including Scifinder (database for the chemical literature) CAS (Chemical Abstract Service) search, web of science, Marin Lit (marine natural products research) database. More than 230 representatives of different classes of alkaloids had been reviewed and classified, different genera belonging to the phylum porifera had been shown to be a prolific source of alkaloidal molecules, including Agelas sp., Suberea sp., Mycale sp., Haliclona sp., Epipolasis sp., Monanchora sp., Crambe sp., Reniera sp., and Xestospongia sp., among others. The sufficient production of alkaloids derived from sponges is a prosperous approach that requires more attention in future studies to consider the constraints regarding the supply of drugs, attained from marine organisms. View Full-Text
Keywords: cytotoxicity; alkaloids; sponges; marine drugs; secondary metabolites cytotoxicity; alkaloids; sponges; marine drugs; secondary metabolites
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MDPI and ACS Style

Elissawy, A.M.; Soleiman Dehkordi, E.; Mehdinezhad, N.; Ashour, M.L.; Mohammadi Pour, P. Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review. Biomolecules 2021, 11, 258. https://doi.org/10.3390/biom11020258

AMA Style

Elissawy AM, Soleiman Dehkordi E, Mehdinezhad N, Ashour ML, Mohammadi Pour P. Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review. Biomolecules. 2021; 11(2):258. https://doi.org/10.3390/biom11020258

Chicago/Turabian Style

Elissawy, Ahmed M.; Soleiman Dehkordi, Ebrahim; Mehdinezhad, Negin; Ashour, Mohamed L.; Mohammadi Pour, Pardis. 2021. "Cytotoxic Alkaloids Derived from Marine Sponges: A Comprehensive Review" Biomolecules 11, no. 2: 258. https://doi.org/10.3390/biom11020258

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