Dynamic mRNP Remodeling in Response to Internal and External Stimuli
Abstract
:1. Introduction
1.1. Nuclear mRNA Processing
1.2. mRNP Assembly and Dynamics
1.3. Nuclear mRNA Export and Its Regulation
1.4. mRNA Translation and Decay in the Cytoplasm
1.5. Principles of Signal Transduction
2. Selected Examples
2.1. mRNP Remodeling Through Protein Modifications
2.1.1. Roles of Post-Translational Modifications in mRNP Remodeling
2.1.2. Regulation of P-Body Factors by Post-Translational Modifications
2.2. RNA Processing Changes in Response to External Signals
2.2.1. Differential Regulation of microRNAs Upon Stress
2.2.2. Responding to Signaling via Alternative Splicing
3. Conclusions
Funding
Conflicts of Interest
References
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RNP | Modification | Functional Effect | Reference |
---|---|---|---|
DDX4 | asymmetric dimethylation | suppression of phase separation | [147] |
hnRNPA2 | asymmetric dimethylation | reduction of phase separation | [148] |
FUS | arginine methylation | reduction of phase separation | [149] [150] |
phosphorylation | reduction of phase separation | [151] | |
LSM4 | symmetric dimethylation of | promotion of P-body formation | [152] |
ELAVL1 | arginine methylation | downregulation of SIRT1-encoding mRNAs | [153] |
U1-70K (SNRNP70) | arginine methylation | recruitment to spliceosome | [154] |
Hpr1 | SUMOylation | promotes association with mRNPs | [141] |
ADAR1 | SUMOylation | impaired RNA editing activity | [155] |
FMRP | phosphorylation | increased interaction with CAPRIN1 increased phase separation | [156] [157] |
CAPRIN1 | phosphorylation | increased interaction with FMRP increased phase separation | [156] |
TDP-43 (TARDBP) | phosphorylation | decreased phase separation | [158] |
TTP | phosphorylation | inhibition of TTP-mediated mRNA destabilization | [128] |
SRSF1 | phosphorylation | reduced binding to target mRNAs | [159] |
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Zarnack, K.; Balasubramanian, S.; Gantier, M.P.; Kunetsky, V.; Kracht, M.; Schmitz, M.L.; Sträßer, K. Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules 2020, 10, 1310. https://doi.org/10.3390/biom10091310
Zarnack K, Balasubramanian S, Gantier MP, Kunetsky V, Kracht M, Schmitz ML, Sträßer K. Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules. 2020; 10(9):1310. https://doi.org/10.3390/biom10091310
Chicago/Turabian StyleZarnack, Kathi, Sureshkumar Balasubramanian, Michael P. Gantier, Vladislav Kunetsky, Michael Kracht, M. Lienhard Schmitz, and Katja Sträßer. 2020. "Dynamic mRNP Remodeling in Response to Internal and External Stimuli" Biomolecules 10, no. 9: 1310. https://doi.org/10.3390/biom10091310