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Dynamic mRNP Remodeling in Response to Internal and External Stimuli

1
Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, 60438 Frankfurt a.M., Germany
2
School of Biological Sciences, Monash University, Clayton, VIC 3800, Australia
3
Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia
4
Department of Molecular and Translational Science, Monash University, Clayton, VIC 3800, Australia
5
Institute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, Germany
6
Rudolf Buchheim Institute of Pharmacology, FB11, Justus Liebig University, 35392 Giessen, Germany
7
Institute of Biochemistry, FB11, Justus Liebig University, 35392 Giessen, Germany
*
Author to whom correspondence should be addressed.
Member of the Cardio Pulmonary Institute (CPI).
Member of the German Center for Lung Research.
Biomolecules 2020, 10(9), 1310; https://doi.org/10.3390/biom10091310
Received: 9 July 2020 / Revised: 2 September 2020 / Accepted: 8 September 2020 / Published: 11 September 2020
(This article belongs to the Special Issue Ribonucleoprotein Particles (RNPs): From Structure to Function)
Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes. View Full-Text
Keywords: signal transduction; extracellular stimuli; intracellular stimuli; stress; post-transcriptional gene regulation; RNA-binding proteins (RBPs); messenger ribonucleoprotein particles (mRNPs) signal transduction; extracellular stimuli; intracellular stimuli; stress; post-transcriptional gene regulation; RNA-binding proteins (RBPs); messenger ribonucleoprotein particles (mRNPs)
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MDPI and ACS Style

Zarnack, K.; Balasubramanian, S.; Gantier, M.P.; Kunetsky, V.; Kracht, M.; Schmitz, M.L.; Sträßer, K. Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules 2020, 10, 1310. https://doi.org/10.3390/biom10091310

AMA Style

Zarnack K, Balasubramanian S, Gantier MP, Kunetsky V, Kracht M, Schmitz ML, Sträßer K. Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules. 2020; 10(9):1310. https://doi.org/10.3390/biom10091310

Chicago/Turabian Style

Zarnack, Kathi, Sureshkumar Balasubramanian, Michael P. Gantier, Vladislav Kunetsky, Michael Kracht, M. L. Schmitz, and Katja Sträßer. 2020. "Dynamic mRNP Remodeling in Response to Internal and External Stimuli" Biomolecules 10, no. 9: 1310. https://doi.org/10.3390/biom10091310

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