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Biogenesis of Mitochondrial Metabolite Carriers
Review

Metabolic Roles of Plant Mitochondrial Carriers

1
Max-Planck-Instiute of Molecular Plant Physiology, 14476 Postdam-Golm, Germany
2
Instituto de Educação, Agricultura e Ambiente, Universidade Federal do Amazonas, Humaitá 69800-000, Amazonas, Brazil
3
Departamento de Biologia Vegetal, Universidade Federal de Viçosa, Viçosa 36570-900, Minas Gerais, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editor: Ferdinando Palmieri
Biomolecules 2020, 10(7), 1013; https://doi.org/10.3390/biom10071013
Received: 24 May 2020 / Revised: 28 June 2020 / Accepted: 29 June 2020 / Published: 8 July 2020
(This article belongs to the Special Issue Mitochondrial Transport Proteins)
Mitochondrial carriers (MC) are a large family (MCF) of inner membrane transporters displaying diverse, yet often redundant, substrate specificities, as well as differing spatio-temporal patterns of expression; there are even increasing examples of non-mitochondrial subcellular localization. The number of these six trans-membrane domain proteins in sequenced plant genomes ranges from 39 to 141, rendering the size of plant families larger than that found in Saccharomyces cerevisiae and comparable with Homo sapiens. Indeed, comparison of plant MCs with those from these better characterized species has been highly informative. Here, we review the most recent comprehensive studies of plant MCFs, incorporating the torrent of genomic data emanating from next-generation sequencing techniques. As such we present a more current prediction of the substrate specificities of these carriers as well as review the continuing quest to biochemically characterize this feature of the carriers. Taken together, these data provide an important resource to guide direct genetic studies aimed at addressing the relevance of these vital carrier proteins. View Full-Text
Keywords: amino acid; biological function; ion; inner mitochondrial membrane; mitochondrial carrier family; organic acid; substrate specificity; transport mechanism; vitamin amino acid; biological function; ion; inner mitochondrial membrane; mitochondrial carrier family; organic acid; substrate specificity; transport mechanism; vitamin
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MDPI and ACS Style

Fernie, A.R.; Cavalcanti, J.H.F.; Nunes-Nesi, A. Metabolic Roles of Plant Mitochondrial Carriers. Biomolecules 2020, 10, 1013. https://doi.org/10.3390/biom10071013

AMA Style

Fernie AR, Cavalcanti JHF, Nunes-Nesi A. Metabolic Roles of Plant Mitochondrial Carriers. Biomolecules. 2020; 10(7):1013. https://doi.org/10.3390/biom10071013

Chicago/Turabian Style

Fernie, Alisdair R., João H.F. Cavalcanti, and Adriano Nunes-Nesi. 2020. "Metabolic Roles of Plant Mitochondrial Carriers" Biomolecules 10, no. 7: 1013. https://doi.org/10.3390/biom10071013

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