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Open AccessArticle

Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study

1
Dipartimento di Scienze e Tecnologie Ambientali, Biologiche, Farmaceutiche, Università della Campania “Luigi Vanvitelli”, Via G. Vivaldi 42, 81100 Caserta, Italy
2
CEINGE—Biotecnologie Avanzate, Via G. Salvatore 486, 80131 Napoli, Italy
3
Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy
4
Department of Advanced Medical and Surgical Sciences, Università della Campania “Luigi Vanvitelli”, Piazza Miraglia, 80138 Naples, Italy
5
Unit of Pharmacology, Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Via Santa Maria di Costantinopoli, 80138 Naples, Italy
6
Department of Translational Medical Sciences, University of Campania “L. Vanvitelli”, 80131 Naples, Italy
7
Monaldi Hospital, 80131 Naples, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to the work.
Biomolecules 2020, 10(6), 926; https://doi.org/10.3390/biom10060926
Received: 1 May 2020 / Revised: 5 June 2020 / Accepted: 16 June 2020 / Published: 18 June 2020
(This article belongs to the Special Issue Advances in Understanding Adipokines in Metabolic Perturbations)
Alterations of adipose tissue occurring in obesity have been recognized as a major risk factor for several cancers. The relationship between adipose tissue and lung cancer, which is the main cancer-related cause of death worldwide, still requires investigation. Perturbations in the adipokine system are likely to interfere with inter-organ crosstalk in lung cancer, which may influence the lung tumor microenvironment. Adiponectin (Acrp30) expression is deregulated in several cancer types. Acrp30 circulates as oligomers with a Low (LMW), Medium (MMW), and High Molecular Weight (HMW), with the latter mediating the main biological effects. Acrp30 acts through AdipoR1 and AdipoR2 receptors. T-cadherin has been described as a non-signaling receptor. This study’s aim was to investigate the regulation of serum Acrp30 and its receptors in sample tissue from non-small cell lung cancer (NSCLC) patients. We recruited 72 NSCLC patients and 60 healthy controls, whom we evaluated in terms of their Acpr30 levels and oligomeric profile. In addition, the expression of AdipoRs in tissues from lung cancer specimens was also measured and compared to coupled healthy lung samples. Our findings show a significant reduction of total Acrp30 levels in NSCLC patients compared to normal subjects, with a specific down-regulation of HMW oligomers. Acrp30 expression was lower in lung adenocarcinoma than other subtypes, regardless of other factors. A significantly higher expression of AdipoR1 was observed, while no differences in R2 and a lower expression of T-cadherin were found in lung cancer specimens compared to normal healthy lung tissues. Involvement of the Acrp30 system in lung cancer may provide new insight into the interaction between adipose tissue and lung and sheds light on its potential ability to influence the lung tumor microenvironment. View Full-Text
Keywords: lung cancer; NSCLC; adiponectin; HMW oligomers; adiponectin receptors lung cancer; NSCLC; adiponectin; HMW oligomers; adiponectin receptors
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Nigro, E.; Perrotta, F.; Monaco, M.L.; Polito, R.; Pafundi, P.C.; Matera, M.G.; Daniele, A.; Bianco, A. Implications of the Adiponectin System in Non-Small Cell Lung Cancer Patients: A Case-Control Study. Biomolecules 2020, 10, 926.

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