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Open AccessArticle

Functional Interactomes of Genes Showing Association with Type-2 Diabetes and Its Intermediate Phenotypic Traits Point towards Adipo-Centric Mechanisms in Its Pathophysiology

1
Department of Biotechnology, Institute of Applied Sciences and Humanities, GLA University, Mathura 281 406, India
2
Department of Bioinformatics, Pathfinder Research and Training Foundation, Gr. Noida 201 308, India
3
Department of Endocrinology, Sawai Man Singh Medical College and Hospital, Jaipur 302 004, India
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(4), 601; https://doi.org/10.3390/biom10040601
Received: 28 January 2020 / Revised: 20 March 2020 / Accepted: 23 March 2020 / Published: 13 April 2020
(This article belongs to the Section Bioinformatics and Systems Biology)
The pathogenic mechanisms causing type 2 diabetes (T2D) are still poorly understood; a greater awareness of its causation can lead to the development of newer and better antidiabetic drugs. In this study, we used a network-based approach to assess the cellular processes associated with protein–protein interaction subnetworks of glycemic traits—HOMA-β and HOMA-IR. Their subnetworks were further analyzed in terms of their overlap with the differentially expressed genes (DEGs) in pancreatic, muscle, and adipose tissue in diabetics. We found several DEGs in these tissues showing an overlap with the HOMA-β subnetwork, suggesting a role of these tissues in β-cell failure. Many genes in the HOMA-IR subnetwork too showed an overlap with the HOMA-β subnetwork. For understanding the functional theme of these subnetworks, a pathway-to-pathway complementary network analysis was done, which identified various adipose biology-related pathways, containing genes involved in both insulin secretion and action. In conclusion, network analysis of genes showing an association between T2D and its intermediate phenotypic traits suggests their potential role in beta cell failure. These genes enriched the adipo-centric pathways and were expressed in both pancreatic and adipose tissue and, therefore, might be one of the potential targets for future antidiabetic treatment. View Full-Text
Keywords: type 2 diabetes; HOMA-β; HOMA-IR; genenetworks type 2 diabetes; HOMA-β; HOMA-IR; genenetworks
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MDPI and ACS Style

Saxena, A.; Wahi, N.; Kumar, A.; Mathur, S.K. Functional Interactomes of Genes Showing Association with Type-2 Diabetes and Its Intermediate Phenotypic Traits Point towards Adipo-Centric Mechanisms in Its Pathophysiology. Biomolecules 2020, 10, 601. https://doi.org/10.3390/biom10040601

AMA Style

Saxena A, Wahi N, Kumar A, Mathur SK. Functional Interactomes of Genes Showing Association with Type-2 Diabetes and Its Intermediate Phenotypic Traits Point towards Adipo-Centric Mechanisms in Its Pathophysiology. Biomolecules. 2020; 10(4):601. https://doi.org/10.3390/biom10040601

Chicago/Turabian Style

Saxena, Aditya; Wahi, Nitin; Kumar, Anshul; Mathur, Sandeep K. 2020. "Functional Interactomes of Genes Showing Association with Type-2 Diabetes and Its Intermediate Phenotypic Traits Point towards Adipo-Centric Mechanisms in Its Pathophysiology" Biomolecules 10, no. 4: 601. https://doi.org/10.3390/biom10040601

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