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Bioenergetics of the Dictyostelium Kinesin-8 Motor Isoform

Division of Translational Medicine, Wadsworth Center, NYS Department of Health, Albany, NY 12237, USA
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Biomolecules 2020, 10(4), 563; https://doi.org/10.3390/biom10040563
Received: 12 March 2020 / Revised: 27 March 2020 / Accepted: 2 April 2020 / Published: 7 April 2020
The functional organization of microtubules in eukaryotic cells requires a combination of their inherent dynamic properties, interactions with motor machineries, and interactions with accessory proteins to affect growth, shrinkage, stability, and architecture. In most organisms, the Kinesin-8 family of motors play an integral role in these organizations, well known for their mitotic activities in microtubule (MT) length control and kinetochore interactions. In Dictyostelium discoideum, the function of Kinesin-8 remains elusive. We present here some biochemical properties and localization data that indicate that this motor (DdKif10) shares some motility properties with other Kinesin-8s but also illustrates differences in microtubule localization and depolymerase action that highlight functional diversity. View Full-Text
Keywords: kinesin; microtubules; Dictyostelium; cell motility kinesin; microtubules; Dictyostelium; cell motility
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Koonce, M.P.; Tikhonenko, I. Bioenergetics of the Dictyostelium Kinesin-8 Motor Isoform. Biomolecules 2020, 10, 563.

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