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Open AccessArticle

High-Density Lipoprotein Particles and Their Relationship to Posttransplantation Diabetes Mellitus in Renal Transplant Recipients

1
Department of Internal Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
2
Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
3
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The Netherlands
4
Laboratory Corporation of America® Holdings (LabCorp), Morrisville, NC 27560, USA
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(3), 481; https://doi.org/10.3390/biom10030481
Received: 14 February 2020 / Revised: 11 March 2020 / Accepted: 19 March 2020 / Published: 21 March 2020
High concentrations of high-density lipoprotein (HDL) cholesterol are likely associated with a lower risk of posttransplantation diabetes mellitus (PTDM). However, HDL particles vary in size and density with yet unestablished associations with PTDM risk. The aim of our study was to determine the association between different HDL particles and development of PTDM in renal transplant recipients (RTRs). We included 351 stable outpatient adult RTRs without diabetes at baseline evaluation. HDL particle characteristics and size were measured by nuclear magnetic resonance (NMR) spectroscopy. During 5.2 (IQR, 4.1‒5.8) years of follow-up, 39 (11%) RTRs developed PTDM. In multivariable Cox regression analysis, levels of HDL cholesterol (hazard ratio [HR] 0.61, 95% confidence interval [CI] 0.40–0.94 per 1SD increase; p = 0.024) and of large HDL particles (HR 0.68, 95% CI 0.50–0.93 per log 1SD increase; p = 0.017), as well as larger HDL size (HR 0.58, 95% CI 0.36–0.93 per 1SD increase; p = 0.025) were inversely associated with PTDM development, independently of relevant covariates including, age, sex, body mass index, medication use, transplantation-specific parameters, blood pressure, triglycerides, and glucose. In conclusion, higher concentrations of HDL cholesterol and of large HDL particles and greater HDL size were associated with a lower risk of PTDM development in RTRs, independently of established risk factors for PTDM development. View Full-Text
Keywords: HDL cholesterol; HDL particles; HDL size; posttransplantation diabetes mellitus; renal transplant recipients HDL cholesterol; HDL particles; HDL size; posttransplantation diabetes mellitus; renal transplant recipients
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MDPI and ACS Style

Sokooti, S.; Szili-Torok, T.; Flores-Guerrero, J.L.; Osté, M.C.J.; Gomes-Neto, A.W.; Kootstra-Ros, J.E.; Heerspink, H.J.L.; Connelly, M.A.; Bakker, S.J.L.; Dullaart, R.P.F. High-Density Lipoprotein Particles and Their Relationship to Posttransplantation Diabetes Mellitus in Renal Transplant Recipients. Biomolecules 2020, 10, 481. https://doi.org/10.3390/biom10030481

AMA Style

Sokooti S, Szili-Torok T, Flores-Guerrero JL, Osté MCJ, Gomes-Neto AW, Kootstra-Ros JE, Heerspink HJL, Connelly MA, Bakker SJL, Dullaart RPF. High-Density Lipoprotein Particles and Their Relationship to Posttransplantation Diabetes Mellitus in Renal Transplant Recipients. Biomolecules. 2020; 10(3):481. https://doi.org/10.3390/biom10030481

Chicago/Turabian Style

Sokooti, Sara; Szili-Torok, Tamas; Flores-Guerrero, Jose L.; Osté, Maryse C.J.; Gomes-Neto, António W.; Kootstra-Ros, Jenny E.; Heerspink, Hiddo J.L.; Connelly, Margery A.; Bakker, Stephan J.L.; Dullaart, Robin P.F. 2020. "High-Density Lipoprotein Particles and Their Relationship to Posttransplantation Diabetes Mellitus in Renal Transplant Recipients" Biomolecules 10, no. 3: 481. https://doi.org/10.3390/biom10030481

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