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Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats

1
Vitamin D research institute, College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, Shaanxi, China
2
College of Biological Science and Engineering, Shaanxi University of Technology, Hanzhong 723000, Shaanxi, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally.
Biomolecules 2020, 10(3), 398; https://doi.org/10.3390/biom10030398
Received: 9 January 2020 / Revised: 27 January 2020 / Accepted: 29 January 2020 / Published: 4 March 2020
Diabetic nephropathy (DN) is one of the most important complications of diabetes, and the leading cause of end-stage renal disease (ESRD). While Chromium picolinate (CrPic) supplementation has been found to be effective in treating diabetes, its effects on diabetic-induced nephropathy have not been studied. Therefore, in this study, CrPic (1 mg kg−1 d−1) was administered to a DN rat model by oral gavage for eight weeks to investigate its effects. The results show that CrPic supplementation caused a decrease in levels of blood glucose, serum insulin, blood urea nitrogen (BUN), serum creatinine, and urinary albumin in DN rats. It also reversed renal pathological changes, including renal glomerular sclerosis and interstitial fibrosis. In addition, the oxidative defense system in the kidneys of DN rats was found to be improved; the biological activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) increased; and the content of malondialdehyde (MDA) lowered. Immunohistochemical results reveal that the expression levels of renal transforming growth factor-β1 (TGF-β1), Smad 2, and Smad 3 decreased significantly in the kidneys of rats in the CrPic-treated group. CrPic administration was thus found to ameliorate diabetic nephropathy in SD rats via an antioxidative stress mechanism, as well the ability to inhibit TGF-β1/Smad2/3 expression. This study suggests that CrPic could be a potential renal-protective nutrient against diabetic nephropathy. View Full-Text
Keywords: diabetic nephropathy; chromium picolinate; renal fibrosis; antioxidative stress diabetic nephropathy; chromium picolinate; renal fibrosis; antioxidative stress
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MDPI and ACS Style

Qi, S.S.; Zheng, H.X.; Jiang, H.; Yuan, L.P.; Dong, L.C. Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats. Biomolecules 2020, 10, 398. https://doi.org/10.3390/biom10030398

AMA Style

Qi SS, Zheng HX, Jiang H, Yuan LP, Dong LC. Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats. Biomolecules. 2020; 10(3):398. https://doi.org/10.3390/biom10030398

Chicago/Turabian Style

Qi, Shan S., Hong X. Zheng, Hai Jiang, Li P. Yuan, and Le C. Dong 2020. "Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats" Biomolecules 10, no. 3: 398. https://doi.org/10.3390/biom10030398

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