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Editorial

Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity

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Goh’s BioComputing, Singapore 548957, Singapore
2
Center for Computational Biology, Indiana and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
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Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
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Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID 83844, USA
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Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
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Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center ‘Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences’, Moscow region, 142290 Pushchino, Russia
*
Authors to whom correspondence should be addressed.
Biomolecules 2020, 10(2), 331; https://doi.org/10.3390/biom10020331
Received: 14 February 2020 / Accepted: 17 February 2020 / Published: 19 February 2020
The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, since September 2012, the WHO has been notified of 2494 laboratory-confirmed cases of infection with MERS-CoV, whereas the 2002–2003 epidemic of SARS affected 26 countries and resulted in more than 8000 cases. Therefore, although SARS, MERS, and COVID-19 are all the result of coronaviral infections, the causes of the coronaviruses differ dramatically in their transmissibility. It is likely that these differences in infectivity of coronaviruses can be attributed to the differences in the rigidity of their shells which can be evaluated using computational tools for predicting intrinsic disorder predisposition of the corresponding viral proteins. View Full-Text
Keywords: COVID-19; Wuhan-2019-nCoV; protein intrinsic disorder; shell disorder; virulence; transmission; nucleocapsid protein; membrane protein COVID-19; Wuhan-2019-nCoV; protein intrinsic disorder; shell disorder; virulence; transmission; nucleocapsid protein; membrane protein
MDPI and ACS Style

Goh, G.K.-M.; Dunker, A.K.; Foster, J.A.; Uversky, V.N. Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity. Biomolecules 2020, 10, 331. https://doi.org/10.3390/biom10020331

AMA Style

Goh GK-M, Dunker AK, Foster JA, Uversky VN. Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity. Biomolecules. 2020; 10(2):331. https://doi.org/10.3390/biom10020331

Chicago/Turabian Style

Goh, Gerard K.-M., A. K. Dunker, James A. Foster, and Vladimir N. Uversky 2020. "Rigidity of the Outer Shell Predicted by a Protein Intrinsic Disorder Model Sheds Light on the COVID-19 (Wuhan-2019-nCoV) Infectivity" Biomolecules 10, no. 2: 331. https://doi.org/10.3390/biom10020331

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