Next Article in Journal
Regulation of Electromagnetic Perceptive Gene Using Ferromagnetic Particles for the External Control of Calcium Ion Transport
Previous Article in Journal
System-Based Differential Gene Network Analysis for Characterizing a Sample-Specific Subnetwork
Previous Article in Special Issue
Follow the Mutations: Toward Class-Specific, Small-Molecule Reactivation of p53
Open AccessReview

p53’s Extended Reach: The Mutant p53 Secretome

Institute of Molecular Oncology, Member of the German Center for Lung Research (DZL), Philipps-University, Hans-Meerwein-Straße 3, 35043 Marburg, Germany
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(2), 307; https://doi.org/10.3390/biom10020307 (registering DOI)
Received: 25 January 2020 / Revised: 10 February 2020 / Accepted: 12 February 2020 / Published: 15 February 2020
(This article belongs to the Special Issue Recent Advances in p53)
p53 suppresses tumorigenesis by activating a plethora of effector pathways. While most of these operate primarily inside of cells to limit proliferation and survival of incipient cancer cells, many extend to the extracellular space. In particular, p53 controls expression and secretion of numerous extracellular factors that are either soluble or contained within extracellular vesicles such as exosomes. As part of the cellular secretome, they execute key roles in cell-cell communication and extracellular matrix remodeling. Mutations in the p53-encoding TP53 gene are the most frequent genetic alterations in cancer cells, and therefore, have profound impact on the composition of the tumor cell secretome. In this review, we discuss how the loss or dominant-negative inhibition of wild-type p53 in concert with a gain of neomorphic properties observed for many mutant p53 proteins, shapes a tumor cell secretome that creates a supportive microenvironment at the primary tumor site and primes niches in distant organs for future metastatic colonization. View Full-Text
Keywords: p53; tumor suppressor; secretome; extracellular vesicles; exosomes; tumor microenvironment; pre-metastatic niches; metastasis p53; tumor suppressor; secretome; extracellular vesicles; exosomes; tumor microenvironment; pre-metastatic niches; metastasis
Show Figures

Figure 1

MDPI and ACS Style

Pavlakis, E.; Stiewe, T. p53’s Extended Reach: The Mutant p53 Secretome. Biomolecules 2020, 10, 307.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop