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Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer

IRCM, Institut de Recherche en Cancérologie de Montpellier, INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, F-34298 Montpellier, France
CNRS—Centre National de la Recherche Scientifique, 1919 Route de Mende, 34293 Montpellier, France
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Present address: CHU Saint Eloi, Montpellier, Service Oncologie Médicale, 80 Avenue Augustin Fliche, 34090 Montpellier, France.
Biomolecules 2020, 10(12), 1659;
Received: 16 November 2020 / Revised: 7 December 2020 / Accepted: 9 December 2020 / Published: 11 December 2020
(This article belongs to the Special Issue Protein Phosphorylation in Cancer: Unraveling the Signaling Pathways)
In this review article, we present the current knowledge on PTPN13, a class I non-receptor protein tyrosine phosphatase identified in 1994. We focus particularly on its role in cancer, where PTPN13 acts as an oncogenic protein and also a tumor suppressor. To try to understand these apparent contradictory functions, we discuss PTPN13 implication in the FAS and oncogenic tyrosine kinase signaling pathways and in the associated biological activities, as well as its post-transcriptional and epigenetic regulation. Then, we describe PTPN13 clinical significance as a prognostic marker in different cancer types and its impact on anti-cancer treatment sensitivity. Finally, we present future research axes following recent findings on its role in cell junction regulation that implicate PTPN13 in cell death and cell migration, two major hallmarks of tumor formation and progression. View Full-Text
Keywords: PTPN13; cell signaling; cancer; tumor suppressor; oncogene PTPN13; cell signaling; cancer; tumor suppressor; oncogene
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MDPI and ACS Style

Mcheik, S.; Aptecar, L.; Coopman, P.; D’Hondt, V.; Freiss, G. Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer. Biomolecules 2020, 10, 1659.

AMA Style

Mcheik S, Aptecar L, Coopman P, D’Hondt V, Freiss G. Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer. Biomolecules. 2020; 10(12):1659.

Chicago/Turabian Style

Mcheik, Soha, Leticia Aptecar, Peter Coopman, Véronique D’Hondt, and Gilles Freiss. 2020. "Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer" Biomolecules 10, no. 12: 1659.

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