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From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues

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Bone and Cartilage Research Unit, Arthropôle Liège, Center for Interdisciplinary research on Medicines (CIRM) Liège, Liège University, Institute of Pathology, CHU Sart-Tilman, 4000 Liège, Belgium
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Biomechanics Research Unit, B34 GIGA-R, In Silico Medicine, Liège University, CHU Sart-Tilman, 4000 Liège, Belgium
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Laboratory for Organogenesis and Regeneration (LOR), GIGA-Research, Liège University, Avenue de l’Hôpital, B-4000 Liège, Belgium
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Physical therapy and Rehabilitation department, Princess Paola Hospital, Vivalia, B-6900 Marche-en-Famenne, Belgium
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Artialis SA, GIGA Tower, Level 3, CHU Sart-Tilman, 4000 Liège, Belgium
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Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 80; https://doi.org/10.3390/biom10010080
Received: 2 December 2019 / Revised: 19 December 2019 / Accepted: 26 December 2019 / Published: 3 January 2020
(This article belongs to the Section Molecular Biology)
The extracellular matrix can trigger cellular responses through its composition and structure. Major extracellular matrix components are the proteoglycans, which are composed of a core protein associated with glycosaminoglycans, among which the small leucine-rich proteoglycans (SLRPs) are the largest family. This review highlights how the codon usage pattern can be used to modulate cellular response and discusses the biological impact of post-translational events on SLRPs, including the substitution of glycosaminoglycan moieties, glycosylation, and degradation. These modifications are listed, and their impacts on the biological activities and structural properties of SLRPs are described. We narrowed the topic to skeletal tissues undergoing dynamic remodeling. View Full-Text
Keywords: small leucine-rich proteoglycans; codon usage; post-translational event; glycosaminoglycan; glycosylation; catabolism small leucine-rich proteoglycans; codon usage; post-translational event; glycosaminoglycan; glycosylation; catabolism
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Zappia, J.; Joiret, M.; Sanchez, C.; Lambert, C.; Geris, L.; Muller, M.; Henrotin, Y. From Translation to Protein Degradation as Mechanisms for Regulating Biological Functions: A Review on the SLRP Family in Skeletal Tissues. Biomolecules 2020, 10, 80.

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