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Open AccessArticle

Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid

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Metallurgy and Materials Science Research Institute, Chulalongkorn University, Bangkok 10330, Thailand
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Natural Products for Ageing and Chronic Diseases Research Unit, Chulalongkorn University, Bangkok 10330, Thailand
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Institute of Nutrition, Mahidol University, Nakhon Pathom 73170, Thailand
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Department of Physics, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
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Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
*
Author to whom correspondence should be addressed.
Biomolecules 2020, 10(1), 73; https://doi.org/10.3390/biom10010073 (registering DOI)
Received: 29 November 2019 / Revised: 25 December 2019 / Accepted: 30 December 2019 / Published: 2 January 2020
(This article belongs to the Section Biological Materials)
Curcumin diglutaric acid-loaded polyethylene glycol-chitosan oligosaccharide-coated superparamagnetic iron oxide nanoparticles (CG-PEG-CSO-SPIONs) were fabricated by co-precipitation and optimized using a Box–Behnken statistical design in order to achieve the minimum size, optimal zeta potential (≥ ±20 mV), and maximum loading efficiency and capacity. The results demonstrated that CG-PEG-CSO-SPIONs prepared under the optimal condition were almost spherical in shape with a smooth surface, a diameter of 130 nm, zeta potential of 30.6 mV, loading efficiency of 83.3%, and loading capacity of 8.3%. The vibrating sample magnetometer results of the optimized CG-PEG-CSO-SPIONs showed a superparamagnetic behavior. Fourier transform infrared spectroscopy and X-ray diffraction analyses indicated that the CG physically interacted with PEG-CSO-SPIONs. In addition, the CG-PEG-CSO-SPIONs could be stored dry for up to 12 weeks or in aqueous solution for up to 4 days at either 4 °C or 25 °C with no loss of stability. The CG-PEG-CSO-SPIONs exhibited a sustained release profile up to 72 h under simulated physiological (pH 7.4) and tumor extracellular (pH 5.5) environments. Furthermore, the CG-PEG-CSO-SPIONs showed little non-specific protein binding in the simulated physiological environment. The CG-PEG-CSO-SPIONs enhanced the cellular uptake and cytotoxicity of CG against human colorectal adenocarcinoma HT-29 cells compared to free CG, and more CG was delivered to the cells after applying an external magnetic field. The overall results suggest that PEG-CSO-SPIONs have potential to be used as a novel drug delivery system for CG. View Full-Text
Keywords: polyethylene glycol; chitosan oligosaccharide; superparamagnetic iron oxide nanoparticles; curcumin diglutaric acid; drug delivery systems polyethylene glycol; chitosan oligosaccharide; superparamagnetic iron oxide nanoparticles; curcumin diglutaric acid; drug delivery systems
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Sorasitthiyanukarn, F.N.; Muangnoi, C.; Thaweesest, W.; Ratnatilaka Na Bhuket, P.; Jantaratana, P.; Rojsitthisak, P.; Rojsitthisak, P. Polyethylene Glycol-Chitosan Oligosaccharide-Coated Superparamagnetic Iron Oxide Nanoparticles: A Novel Drug Delivery System for Curcumin Diglutaric Acid. Biomolecules 2020, 10, 73.

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